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Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

Objectives: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the under...

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Detalles Bibliográficos
Autores Principales: Kaufman, Kenneth M, Zhao, Jian, Kelly, Jennifer A, Hughes, Travis, Adler, Adam, Sanchez, Elena, Ojwang, Joshua O, Langefeld, Carl D, Ziegler, Julie T, Williams, Adrienne H, Comeau, Mary E, Marion, Miranda C, Glenn, Stuart B, Cantor, Rita M, Grossman, Jennifer M, Hahn, Bevra H, Song, Yeong Wook, Yu, Chack-Yung, James, Judith A, Guthridge, Joel M, Brown, Elizabeth E, Alarcón, Graciela S, Kimberly, Robert P, Edberg, Jeffrey C, Ramsey-Goldman, Rosalind, Petri, Michelle A, Reveille, John D, Vilá, Luis M, Anaya, Juan-Manuel, Boackle, Susan A, Stevens, Anne M, Freedman, Barry I, Criswell, Lindsey A, Pons Estel, Bernardo A, Lee, Joo-Hyun, Lee, Ji-Seon, Chang, Deh-Ming, Scofield, R Hal A, Gilkeson, Gary S, Merrill, Joan T, Niewold, Timothy B, Vyse, Timothy James, Bae, Sang-Cheol, Alarcón-Riquelme, Marta E, Jacob, Chaim O, Moser Sivils, Kathy, Gaffney, Patrick M, Harley, John B, Sawalha, Amr H, Tsao, Betty P
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2013
Materias:
Immunoglobulin enhancer binding protein
Interleukin 1 receptor associated kinase 1
Messenger rna
Methyl cpg binding protein 2
Amino acid substitution
Arhgap4 gene
Article
Asian
Avpr2 gene
Case control study
Chromosome xq
Chromosome xq28
Controlled study
Ethnic difference
European american
Gene
Gene location
Gene mapping
Genetic association
Genetic risk
Genetic susceptibility
Genotype
Haplotype
Hcfc1 gene
Hispanic
Human
Irak1 gene
L1cam gene
Major clinical study
Mecp2 gene
Naa10 gene
Negro
Plesiomorphy
Priority journal
Protein function
Real time polymerase chain reaction
Renbp gene
Single nucleotide polymorphism
Systemic lupus erythematosus
Tmem187 gene
Base sequence
Chromosome mapping
Continental population groups
Genetic predisposition to disease
Haplotypes
Humans
Interleukin-1 receptor-associated kinases
Methyl-cpg-binding protein 2
Molecular sequence data
Real-time polymerase chain reaction
Risk factors
systemic
single nucleotide
human
Chromosomes
Lupus erythematosus
Polymorphism
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22422
https://doi.org/10.1136/annrheumdis-2012-201851

Internet

https://repository.urosario.edu.co/handle/10336/22422
https://doi.org/10.1136/annrheumdis-2012-201851

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