Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients
Analysis of genetic susceptibility factors for Alzheimer's disease (AD) in populations with different genetic and environmental background may be useful to understand AD etiology. There are few genetic association studies of AD in Latin America. In the present work, we analyzed polymorphisms in...
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ir-10336-224082022-05-02T12:37:20Z Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients Forero D.A. Arboleda G. Yunis J.J. Pardo R. Arboleda H. Apolipoprotein E Low density lipoprotein receptor related protein 1 Protein Serotonin transporter Tau protein Unclassified drug Adult Aged Allele Alzheimer disease Article Colombia Controlled study Disease association DNA polymorphism Female Genetic susceptibility Genotype Human Major clinical study Male Microtubule Multivariate analysis Nerve cell network Population research Priority journal Risk factor South and Central America Statistical analysis Stratification Aged Alleles Alzheimer Disease Apolipoprotein E4 Colombia Female Gene Frequency Genotype Humans LDL-Receptor Related Protein 1 Male Middle Aged Minisatellite Repeats Reverse Transcriptase Polymerase Chain Reaction Risk Factors Serotonin Plasma Membrane Transport Proteins Tau Proteins Alzheimer's disease Colombia Genetic association Analysis of genetic susceptibility factors for Alzheimer's disease (AD) in populations with different genetic and environmental background may be useful to understand AD etiology. There are few genetic association studies of AD in Latin America. In the present work, we analyzed polymorphisms in 3 candidate genes; the LDL receptor related protein-1, the microtubule-associated protein Tau and the serotonin transporter genes in a sample of 106 Colombian AD patients and 97 control subjects. We did not find a significant allelic or genotypic association with any of the three polymorphisms analyzed using different statistical analysis, including a neural network model or different sample stratifications. To date, APOE polymorphisms are the only genetic risk factors identified for AD in the Colombian population. It may be factible that future combination of high-throughput genotyping platforms and multivariate analysis models may lead to the identification of other genetic susceptibility factors for AD in the Colombian population. © Springer-Verlag 2005. 2006 2020-05-25T23:56:22Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 3009564 https://repository.urosario.edu.co/handle/10336/22408 https://doi.org/10.1007/s00702-005-0388-z eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
institution |
EdocUR - Universidad del Rosario |
collection |
DSpace |
language |
Inglés (English) |
topic |
Apolipoprotein E Low density lipoprotein receptor related protein 1 Protein Serotonin transporter Tau protein Unclassified drug Adult Aged Allele Alzheimer disease Article Colombia Controlled study Disease association DNA polymorphism Female Genetic susceptibility Genotype Human Major clinical study Male Microtubule Multivariate analysis Nerve cell network Population research Priority journal Risk factor South and Central America Statistical analysis Stratification Aged Alleles Alzheimer Disease Apolipoprotein E4 Colombia Female Gene Frequency Genotype Humans LDL-Receptor Related Protein 1 Male Middle Aged Minisatellite Repeats Reverse Transcriptase Polymerase Chain Reaction Risk Factors Serotonin Plasma Membrane Transport Proteins Tau Proteins Alzheimer's disease Colombia Genetic association |
spellingShingle |
Apolipoprotein E Low density lipoprotein receptor related protein 1 Protein Serotonin transporter Tau protein Unclassified drug Adult Aged Allele Alzheimer disease Article Colombia Controlled study Disease association DNA polymorphism Female Genetic susceptibility Genotype Human Major clinical study Male Microtubule Multivariate analysis Nerve cell network Population research Priority journal Risk factor South and Central America Statistical analysis Stratification Aged Alleles Alzheimer Disease Apolipoprotein E4 Colombia Female Gene Frequency Genotype Humans LDL-Receptor Related Protein 1 Male Middle Aged Minisatellite Repeats Reverse Transcriptase Polymerase Chain Reaction Risk Factors Serotonin Plasma Membrane Transport Proteins Tau Proteins Alzheimer's disease Colombia Genetic association Forero D.A. Arboleda G. Yunis J.J. Pardo R. Arboleda H. Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients |
description |
Analysis of genetic susceptibility factors for Alzheimer's disease (AD) in populations with different genetic and environmental background may be useful to understand AD etiology. There are few genetic association studies of AD in Latin America. In the present work, we analyzed polymorphisms in 3 candidate genes; the LDL receptor related protein-1, the microtubule-associated protein Tau and the serotonin transporter genes in a sample of 106 Colombian AD patients and 97 control subjects. We did not find a significant allelic or genotypic association with any of the three polymorphisms analyzed using different statistical analysis, including a neural network model or different sample stratifications. To date, APOE polymorphisms are the only genetic risk factors identified for AD in the Colombian population. It may be factible that future combination of high-throughput genotyping platforms and multivariate analysis models may lead to the identification of other genetic susceptibility factors for AD in the Colombian population. © Springer-Verlag 2005. |
format |
Artículo (Article) |
author |
Forero D.A. Arboleda G. Yunis J.J. Pardo R. Arboleda H. |
author_facet |
Forero D.A. Arboleda G. Yunis J.J. Pardo R. Arboleda H. |
author_sort |
Forero D.A. |
title |
Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients |
title_short |
Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients |
title_full |
Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients |
title_fullStr |
Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients |
title_full_unstemmed |
Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients |
title_sort |
association study of polymorphisms in lrp1, tau and 5-htt genes and alzheimer's disease in a sample of colombian patients |
publishDate |
2006 |
url |
https://repository.urosario.edu.co/handle/10336/22408 https://doi.org/10.1007/s00702-005-0388-z |
_version_ |
1740172266555047936 |
score |
12,131701 |