The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers

Disseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneit...

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Autores Principales: Nacher, Mathieu, Leitao, Terezinha Silva, Gómez, Beatriz L., Couppié, Pierre, Adenis, Antoine, Damasceno, Lisandra, Demar, Magalie, Samayoa, Blanca, Cáceres, Diego H., Pradinaud, Roger, de Queiroz Sousa, Anastacio, Arathoon, Eduardo, Restrepo, Angela
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: MDPI AG 2019
Materias:
Hiv
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22349
https://doi.org/10.3390/jof5020051
id ir-10336-22349
recordtype dspace
spelling ir-10336-223492022-05-02T12:37:14Z The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers Nacher, Mathieu Leitao, Terezinha Silva Gómez, Beatriz L. Couppié, Pierre Adenis, Antoine Damasceno, Lisandra Demar, Magalie Samayoa, Blanca Cáceres, Diego H. Pradinaud, Roger de Queiroz Sousa, Anastacio Arathoon, Eduardo Restrepo, Angela Awareness Histoplasmosis Hiv Latin america Leishmaniasis Disseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneity in the level of histoplasmosis awareness. The purpose of this report was to describe how the historical “awakening” to the threat of histoplasmosis came to be in four different centers that have actively described this disease: In Brazil, the Sao José hospital in Fortaleza; in Colombia, the Corporación para Investigaciones Biológicas inMedellin; in French Guiana, Cayenne Hospital; and in Guatemala, the Association de Salud Integral in Guatemala city. In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. With time and progress in fungal culture, the magnitude of this problem turned it into a local priority. In Colombia and Guatemala, the story is different because for these mycology centers, it was no surprise to find histoplasmosis in HIV patients. In addition, collaborations with the CDC to evaluate antigen-detection tests resulted in researchers and clinicians developing the capacity to rapidly screen most patients and to demonstrate the very high burden of disease in these countries. While the lack of awareness is still a major problem, it is instructive to review the ways through which different centers became histoplasmosis-aware. Nevertheless, as new rapid diagnostic tools are becoming available, their implementation throughout Latin America should rapidly raise the level of awareness in order to reduce the burden of histoplasmosis deaths. © 2019 by the authors. 2019 2020-05-25T23:56:10Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://repository.urosario.edu.co/handle/10336/22349 https://doi.org/10.3390/jof5020051 eng info:eu-repo/semantics/openAccess application/pdf MDPI AG instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Awareness
Histoplasmosis
Hiv
Latin america
Leishmaniasis
spellingShingle Awareness
Histoplasmosis
Hiv
Latin america
Leishmaniasis
Nacher, Mathieu
Leitao, Terezinha Silva
Gómez, Beatriz L.
Couppié, Pierre
Adenis, Antoine
Damasceno, Lisandra
Demar, Magalie
Samayoa, Blanca
Cáceres, Diego H.
Pradinaud, Roger
de Queiroz Sousa, Anastacio
Arathoon, Eduardo
Restrepo, Angela
The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers
description Disseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneity in the level of histoplasmosis awareness. The purpose of this report was to describe how the historical “awakening” to the threat of histoplasmosis came to be in four different centers that have actively described this disease: In Brazil, the Sao José hospital in Fortaleza; in Colombia, the Corporación para Investigaciones Biológicas inMedellin; in French Guiana, Cayenne Hospital; and in Guatemala, the Association de Salud Integral in Guatemala city. In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. With time and progress in fungal culture, the magnitude of this problem turned it into a local priority. In Colombia and Guatemala, the story is different because for these mycology centers, it was no surprise to find histoplasmosis in HIV patients. In addition, collaborations with the CDC to evaluate antigen-detection tests resulted in researchers and clinicians developing the capacity to rapidly screen most patients and to demonstrate the very high burden of disease in these countries. While the lack of awareness is still a major problem, it is instructive to review the ways through which different centers became histoplasmosis-aware. Nevertheless, as new rapid diagnostic tools are becoming available, their implementation throughout Latin America should rapidly raise the level of awareness in order to reduce the burden of histoplasmosis deaths. © 2019 by the authors.
format Artículo (Article)
author Nacher, Mathieu
Leitao, Terezinha Silva
Gómez, Beatriz L.
Couppié, Pierre
Adenis, Antoine
Damasceno, Lisandra
Demar, Magalie
Samayoa, Blanca
Cáceres, Diego H.
Pradinaud, Roger
de Queiroz Sousa, Anastacio
Arathoon, Eduardo
Restrepo, Angela
author_facet Nacher, Mathieu
Leitao, Terezinha Silva
Gómez, Beatriz L.
Couppié, Pierre
Adenis, Antoine
Damasceno, Lisandra
Demar, Magalie
Samayoa, Blanca
Cáceres, Diego H.
Pradinaud, Roger
de Queiroz Sousa, Anastacio
Arathoon, Eduardo
Restrepo, Angela
author_sort Nacher, Mathieu
title The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers
title_short The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers
title_full The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers
title_fullStr The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers
title_full_unstemmed The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers
title_sort fight against hiv-associated disseminated histoplasmosis in the americas: unfolding the different stories of four centers
publisher MDPI AG
publishDate 2019
url https://repository.urosario.edu.co/handle/10336/22349
https://doi.org/10.3390/jof5020051
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score 12,131701