Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease

"Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (E...

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Autores Principales: "Zandman?Goddard, Gisele, Berkun, Yackov, Barzilai, Ori, Boaz, Mona, Blank, Miri, Ram, Maya, Sherer, Yaniv, Anaya, Juan Manuel, Shoenfeld, Yehuda"
Formato: Objeto de conferencia (Conference Object)
Lenguaje:Inglés (English)
Publicado: Blackwell Publishing Inc. 2009
Materias:
Abs
Ebv
Sle
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22333
https://doi.org/10.1111/j.1749-6632.2009.04754.x
id ir-10336-22333
recordtype dspace
spelling ir-10336-223332020-06-03T22:15:03Z Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease "Zandman?Goddard, Gisele Berkun, Yackov Barzilai, Ori Boaz, Mona Blank, Miri Ram, Maya Sherer, Yaniv Anaya, Juan Manuel Shoenfeld, Yehuda" Cell nucleus antigen Early antigen Heterophile antibody Heterophile antigen Immunoglobulin g Immunoglobulin m Virus capsid antigen Adult Antibody titer Conference paper Control group Controlled study Disease association Disease severity Epstein barr virus Human Human cell Human tissue Major clinical study Phenotype Prediction Systemic lupus erythematosus Virus capsid Virus infection Human herpesvirus 4 Miridae Abs Ebv Lupus Mild disease Sle "Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P less than 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P less than 0.005). VCA IgG titers were significantly elevated (P less than 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs. © 2009 New York Academy of Sciences." 2009 2020-05-25T23:56:08Z info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion 778923 https://repository.urosario.edu.co/handle/10336/22333 https://doi.org/10.1111/j.1749-6632.2009.04754.x eng info:eu-repo/semantics/openAccess application/pdf Blackwell Publishing Inc. instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Cell nucleus antigen
Early antigen
Heterophile antibody
Heterophile antigen
Immunoglobulin g
Immunoglobulin m
Virus capsid antigen
Adult
Antibody titer
Conference paper
Control group
Controlled study
Disease association
Disease severity
Epstein barr virus
Human
Human cell
Human tissue
Major clinical study
Phenotype
Prediction
Systemic lupus erythematosus
Virus capsid
Virus infection
Human herpesvirus 4
Miridae
Abs
Ebv
Lupus
Mild disease
Sle
spellingShingle Cell nucleus antigen
Early antigen
Heterophile antibody
Heterophile antigen
Immunoglobulin g
Immunoglobulin m
Virus capsid antigen
Adult
Antibody titer
Conference paper
Control group
Controlled study
Disease association
Disease severity
Epstein barr virus
Human
Human cell
Human tissue
Major clinical study
Phenotype
Prediction
Systemic lupus erythematosus
Virus capsid
Virus infection
Human herpesvirus 4
Miridae
Abs
Ebv
Lupus
Mild disease
Sle
"Zandman?Goddard, Gisele
Berkun, Yackov
Barzilai, Ori
Boaz, Mona
Blank, Miri
Ram, Maya
Sherer, Yaniv
Anaya, Juan Manuel
Shoenfeld, Yehuda"
Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease
description "Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P less than 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P less than 0.005). VCA IgG titers were significantly elevated (P less than 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs. © 2009 New York Academy of Sciences."
format Objeto de conferencia (Conference Object)
author "Zandman?Goddard, Gisele
Berkun, Yackov
Barzilai, Ori
Boaz, Mona
Blank, Miri
Ram, Maya
Sherer, Yaniv
Anaya, Juan Manuel
Shoenfeld, Yehuda"
author_facet "Zandman?Goddard, Gisele
Berkun, Yackov
Barzilai, Ori
Boaz, Mona
Blank, Miri
Ram, Maya
Sherer, Yaniv
Anaya, Juan Manuel
Shoenfeld, Yehuda"
author_sort "Zandman?Goddard, Gisele
title Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease
title_short Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease
title_full Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease
title_fullStr Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease
title_full_unstemmed Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease
title_sort exposure to epstein-barr virus infection is associated with mild systemic lupus erythematosus disease
publisher Blackwell Publishing Inc.
publishDate 2009
url https://repository.urosario.edu.co/handle/10336/22333
https://doi.org/10.1111/j.1749-6632.2009.04754.x
_version_ 1669098253585481728
score 11,389159