The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease
Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in peop...
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BMJ Publishing Group
2016
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22309 https://doi.org/10.1136/jclinpath-2015-203455 |
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ir-10336-223092022-05-02T12:37:20Z The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease Kerr, Jonathan R Angiotensin 1 receptor Autoantibody Autoantigen Cardiolipin Collagen type 2 Fibrinogen receptor Glutamate decarboxylase Glycoprotein iib Keratin Myelin basic protein Phospholipase Rheumatoid factor Autoantibody Autoantigen Aplastic crisis Arthralgia Autoimmune disease Brachial plexus neuropathy Cerebellar ataxia Chronic fatigue syndrome Cranial nerve paralysis Cytopenia Enzyme activity Erythema infectiosum Erythrocyte lifespan Fetus death Graves disease Guillain barre syndrome Heart disease Hematologic disease Human Human parvovirus b19 Immune response Insulin dependent diabetes mellitus Myalgia Myelitis Myositis Neurologic disease Nonhuman Pathogenesis Persistent infection Priority journal Rash Review Rheumatoid arthritis T lymphocyte Thyroid disease Virus transmission Autoimmune disease Autoimmunity Cross reaction Erythema infectiosum Human parvovirus b19 Immunology Molecular mimicry Virology Autoantibodies Autoantigens Autoimmune diseases Autoimmunity Cross reactions Erythema infectiosum Humans Molecular mimicry human Parvovirus b19 Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been shown to be key to the pathogenesis of the particular disease process in a significant number of cases, for example, production of rheumatoid factor in cases of B19-associated rheumatoid arthritis and production of anti-glutamic acid decarboxylase (GAD) in patients with B19-associated type 1 diabetes mellitus. B19 infection has also been associated with the development of multiple autoimmune diseases in 12 individuals. Documented mechanisms in B19-associated autoimmunity include molecular mimicry (IgG antibody to B19 proteins has been shown to cross react with a variety of recognised human autoantigens, including collagen II, keratin, angiotensin II type 1 receptor, myelin basic protein, cardiolipin, and platelet membrane glycoprotein IIb/IIIa), B19-induced apoptosis with presentation of self-antigens to T lymphocytes, and the phospholipase activity of the B19 unique VP1 protein. 2016 2020-05-25T23:56:04Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://repository.urosario.edu.co/handle/10336/22309 https://doi.org/10.1136/jclinpath-2015-203455 eng info:eu-repo/semantics/openAccess application/pdf BMJ Publishing Group instname:Universidad del Rosario |
| institution |
EdocUR - Universidad del Rosario |
| collection |
DSpace |
| language |
Inglés (English) |
| topic |
Angiotensin 1 receptor Autoantibody Autoantigen Cardiolipin Collagen type 2 Fibrinogen receptor Glutamate decarboxylase Glycoprotein iib Keratin Myelin basic protein Phospholipase Rheumatoid factor Autoantibody Autoantigen Aplastic crisis Arthralgia Autoimmune disease Brachial plexus neuropathy Cerebellar ataxia Chronic fatigue syndrome Cranial nerve paralysis Cytopenia Enzyme activity Erythema infectiosum Erythrocyte lifespan Fetus death Graves disease Guillain barre syndrome Heart disease Hematologic disease Human Human parvovirus b19 Immune response Insulin dependent diabetes mellitus Myalgia Myelitis Myositis Neurologic disease Nonhuman Pathogenesis Persistent infection Priority journal Rash Review Rheumatoid arthritis T lymphocyte Thyroid disease Virus transmission Autoimmune disease Autoimmunity Cross reaction Erythema infectiosum Human parvovirus b19 Immunology Molecular mimicry Virology Autoantibodies Autoantigens Autoimmune diseases Autoimmunity Cross reactions Erythema infectiosum Humans Molecular mimicry human Parvovirus b19 |
| spellingShingle |
Angiotensin 1 receptor Autoantibody Autoantigen Cardiolipin Collagen type 2 Fibrinogen receptor Glutamate decarboxylase Glycoprotein iib Keratin Myelin basic protein Phospholipase Rheumatoid factor Autoantibody Autoantigen Aplastic crisis Arthralgia Autoimmune disease Brachial plexus neuropathy Cerebellar ataxia Chronic fatigue syndrome Cranial nerve paralysis Cytopenia Enzyme activity Erythema infectiosum Erythrocyte lifespan Fetus death Graves disease Guillain barre syndrome Heart disease Hematologic disease Human Human parvovirus b19 Immune response Insulin dependent diabetes mellitus Myalgia Myelitis Myositis Neurologic disease Nonhuman Pathogenesis Persistent infection Priority journal Rash Review Rheumatoid arthritis T lymphocyte Thyroid disease Virus transmission Autoimmune disease Autoimmunity Cross reaction Erythema infectiosum Human parvovirus b19 Immunology Molecular mimicry Virology Autoantibodies Autoantigens Autoimmune diseases Autoimmunity Cross reactions Erythema infectiosum Humans Molecular mimicry human Parvovirus b19 Kerr, Jonathan R The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease |
| description |
Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been shown to be key to the pathogenesis of the particular disease process in a significant number of cases, for example, production of rheumatoid factor in cases of B19-associated rheumatoid arthritis and production of anti-glutamic acid decarboxylase (GAD) in patients with B19-associated type 1 diabetes mellitus. B19 infection has also been associated with the development of multiple autoimmune diseases in 12 individuals. Documented mechanisms in B19-associated autoimmunity include molecular mimicry (IgG antibody to B19 proteins has been shown to cross react with a variety of recognised human autoantigens, including collagen II, keratin, angiotensin II type 1 receptor, myelin basic protein, cardiolipin, and platelet membrane glycoprotein IIb/IIIa), B19-induced apoptosis with presentation of self-antigens to T lymphocytes, and the phospholipase activity of the B19 unique VP1 protein. |
| format |
Artículo (Article) |
| author |
Kerr, Jonathan R |
| author_facet |
Kerr, Jonathan R |
| author_sort |
Kerr, Jonathan R |
| title |
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease |
| title_short |
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease |
| title_full |
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease |
| title_fullStr |
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease |
| title_full_unstemmed |
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease |
| title_sort |
role of parvovirus b19 in the pathogenesis of autoimmunity and autoimmune disease |
| publisher |
BMJ Publishing Group |
| publishDate |
2016 |
| url |
https://repository.urosario.edu.co/handle/10336/22309 https://doi.org/10.1136/jclinpath-2015-203455 |
| _version_ |
1740172455997079552 |
| score |
12,131701 |