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BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with gdf9

Context: Bone morphogenetic protein (BMP)15 is an oocyte-specific growth factor, which, together with growth differentiation factor (GDF) 9, regulates folliculogenesis and ovulation rate. Multiple mutations in BMP15 have been identified in women with primary ovarian insufficiency (POI), supporting a...

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Detalles Bibliográficos
Autores Principales: Patiño, Liliana C., Walton, Kelly L., Mueller, Thomas D., Johnson, Katharine E., Stocker, William, Richani, Dulama, Agapiou, David, Gilchrist, Robert B., Laissue, Paul, Harrison, Craig A.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Endocrine Society 2017
Materias:
Bone morphogenetic protein 15
Cysteine
Growth differentiation factor 9
Guanine
Histone
Tyrosine
Adult
Amino acid substitution
Article
Bmp15 gene
Cell activation
Controlled study
Down regulation
Female
Gene expression regulation
Gene function
Gene mutation
Gene sequence
Genetic association
Genetic variability
Granulosa cell
Human
Major clinical study
Mutational analysis
Premature ovarian failure
Protein function
Protein secondary structure
Protein secretion
Protein synthesis
Wild type
Drug effect
Gene expression
Genetics
Metabolism
Molecular model
Mutation
Reverse transcription polymerase chain reaction
Tumor cell line
Granulosa cells
Humans
Primary ovarian insufficiency
Reverse transcriptase polymerase chain reaction
human
molecular
tumor
Bmp15 protein
Gdf9 protein
Cell line
Models
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22298
https://doi.org/10.1210/jc.2016-3503

Internet

https://repository.urosario.edu.co/handle/10336/22298
https://doi.org/10.1210/jc.2016-3503

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