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Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions

P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) are ATP binding cassette (ABC) transporters that are overexpressed in different drug-resistant cancer cell lines. In this study, we investigated whether doxorubicin promotes Pgp and/or BCRP expression to induce drug resistance in colon...

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Detalles Bibliográficos
Autores Principales: Pinzón-Daza M.L., Cuellar-Saenz Y., Nualart F., Ondo-Méndez, Alejandro, Del Riesgo Prendes, Lilia, Castillo-Rivera F., Garzón R.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Wiley-Liss Inc. 2017
Materias:
Breast cancer resistance protein
Cobalt chloride
Doxorubicin
E 3330
Hypoxia inducible factor 1alpha
Lyase inhibitor
Multidrug resistance protein
Reactive oxygen metabolite
Unclassified drug
Dna (apurinic or apyrimidinic site) lyase
Multidrug resistance protein 1
Tumor protein
Article
Cancer growth
Cancer resistance
Cancer survival
Colon cancer
Confocal microscopy
Controlled study
Enzyme linked immunosorbent assay
Ht-29 cell line
Human
Human cell
Hypoxia
Oxidative stress
Priority journal
Protein expression
Reverse transcription polymerase chain reaction
Cell hypoxia
Cell survival
Colon tumor
Drug effects
Genetics
Metabolism
Physiology
Tumor cell line
Colonic neoplasms
Dna-(apurinic or apyrimidinic site) lyase
Enzyme-linked immunosorbent assay
Ht29 cells
Humans
Neoplasm proteins
Reactive oxygen species
Drug resistance
P-glycoprotein
confocal
tumor
human
alpha subunit
sub-family g
sub-family b
member 1
member 2
Abcg2 protein
Apex1 protein
Hif1a protein
Atp binding cassette transporter
Atp-binding cassette
Cell line
Hypoxia-inducible factor 1
Microscopy
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22281
https://doi.org/10.1002/jcb.25890

Internet

https://repository.urosario.edu.co/handle/10336/22281
https://doi.org/10.1002/jcb.25890

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