Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model
Hepatitis-B vaccine (HBVv) can prevent HBV-infection and associated liver diseases. However, concerns regarding its safety, particularly among patients with autoimmune diseases (i.e. SLE) were raised. Moreover, the aluminum adjuvant in HBVv was related to immune mediated adverse events. Therefore, w...
| Autores Principales: | , , , , , , , , , , |
|---|---|
| Formato: | Artículo (Article) |
| Lenguaje: | Inglés (English) |
| Publicado: |
Academic Press
2014
|
| Materias: | |
| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22257 https://doi.org/10.1016/j.jaut.2014.06.006 |
| id |
ir-10336-22257 |
|---|---|
| recordtype |
dspace |
| spelling |
ir-10336-222572022-05-02T12:37:20Z Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model Agmon-Levin, Nancy Arango, María-Teresa Kivity, Shaye Katzav, Aviva Gilburd, Boris Blank, Miri Tomer, Nir Volkov, Alex Barshack, Iris Chapman, Joab Shoenfeld, Yehuda Aluminum hydroxide Double stranded dna antibody Hepatitis b surface antigen Immunological adjuvant Phosphate buffered saline Recombinant hepatitis b vaccine Antinuclear antibody Hepatitis b vaccine Animal experiment Animal model Animal tissue Antibody titer Anxiety Article Autoimmune disease Blood cell count Brain histology Brain region Cell lineage Cognition Controlled study Disease exacerbation Drug safety Erythrocyte Female Forced swim test Gliosis Immunization Kidney disease Lupus like syndrome Memory disorder Microglia Mouse Nonhuman Novel object recognition test Proteinuria Staircase test Systemic lupus erythematosus Y-maze test Animal Brain Disease model Drug effects Immunology Lupus erythematosus nephritis Pathology Pathophysiology Animals Brain Cognition Female Hepatitis b vaccines Lupus nephritis Mice Proteinuria Autoimmune/autoinflammatory syndrome induced by adjuvant (asia) Autoimmunity Hepatitis b vaccine Neuro-cognitive tests Sle Vaccination animal antinuclear Antibodies Disease models Hepatitis-B vaccine (HBVv) can prevent HBV-infection and associated liver diseases. However, concerns regarding its safety, particularly among patients with autoimmune diseases (i.e. SLE) were raised. Moreover, the aluminum adjuvant in HBVv was related to immune mediated adverse events. Therefore, we examined the effects of immunization with HBVv or alum on SLE-like disease in a murine model.NZBWF1 mice were immunized with HBVv (Engerix), or aluminum hydroxide (alum) or phosphate buffered saline (PBS) at 8 and 12 weeks of age. Mice were followed for weight, autoantibodies titers, blood counts, proteinuria, kidney histology, neurocognitive functions (novel object recognition, staircase, Y-maze and the forced swimming tests) and brain histology.Immunization with HBVv induced acceleration of kidney disease manifested by high anti-dsDNA antibodies (. p less than 0.01), early onset of proteinuria (. p less than 0.05), histological damage and deposition of HBs antigen in the kidney. Mice immunized with HBVv and/or alum had decreased cells counts mainly of the red cell lineage (. p less than 0.001), memory deficits (. p less than 0.01), and increased activated microglia in different areas of the brain compare with mice immunized with PBS. Anxiety-like behavior was more pronounced among mice immunized with alum.In conclusion, herein we report that immunization with the HBVv aggravated kidney disease in an animal model of SLE. Immunization with either HBVv or alum affected blood counts, neurocognitive functions and brain gliosis. Our data support the concept that different component of vaccines may be linked with immune and autoimmune mediated adverse events. © 2014 Elsevier Ltd. 2014 2020-05-25T23:55:54Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 10959157 08968411 https://repository.urosario.edu.co/handle/10336/22257 https://doi.org/10.1016/j.jaut.2014.06.006 eng info:eu-repo/semantics/openAccess application/pdf Academic Press instname:Universidad del Rosario |
| institution |
EdocUR - Universidad del Rosario |
| collection |
DSpace |
| language |
Inglés (English) |
| topic |
Aluminum hydroxide Double stranded dna antibody Hepatitis b surface antigen Immunological adjuvant Phosphate buffered saline Recombinant hepatitis b vaccine Antinuclear antibody Hepatitis b vaccine Animal experiment Animal model Animal tissue Antibody titer Anxiety Article Autoimmune disease Blood cell count Brain histology Brain region Cell lineage Cognition Controlled study Disease exacerbation Drug safety Erythrocyte Female Forced swim test Gliosis Immunization Kidney disease Lupus like syndrome Memory disorder Microglia Mouse Nonhuman Novel object recognition test Proteinuria Staircase test Systemic lupus erythematosus Y-maze test Animal Brain Disease model Drug effects Immunology Lupus erythematosus nephritis Pathology Pathophysiology Animals Brain Cognition Female Hepatitis b vaccines Lupus nephritis Mice Proteinuria Autoimmune/autoinflammatory syndrome induced by adjuvant (asia) Autoimmunity Hepatitis b vaccine Neuro-cognitive tests Sle Vaccination animal antinuclear Antibodies Disease models |
| spellingShingle |
Aluminum hydroxide Double stranded dna antibody Hepatitis b surface antigen Immunological adjuvant Phosphate buffered saline Recombinant hepatitis b vaccine Antinuclear antibody Hepatitis b vaccine Animal experiment Animal model Animal tissue Antibody titer Anxiety Article Autoimmune disease Blood cell count Brain histology Brain region Cell lineage Cognition Controlled study Disease exacerbation Drug safety Erythrocyte Female Forced swim test Gliosis Immunization Kidney disease Lupus like syndrome Memory disorder Microglia Mouse Nonhuman Novel object recognition test Proteinuria Staircase test Systemic lupus erythematosus Y-maze test Animal Brain Disease model Drug effects Immunology Lupus erythematosus nephritis Pathology Pathophysiology Animals Brain Cognition Female Hepatitis b vaccines Lupus nephritis Mice Proteinuria Autoimmune/autoinflammatory syndrome induced by adjuvant (asia) Autoimmunity Hepatitis b vaccine Neuro-cognitive tests Sle Vaccination animal antinuclear Antibodies Disease models Agmon-Levin, Nancy Arango, María-Teresa Kivity, Shaye Katzav, Aviva Gilburd, Boris Blank, Miri Tomer, Nir Volkov, Alex Barshack, Iris Chapman, Joab Shoenfeld, Yehuda Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model |
| description |
Hepatitis-B vaccine (HBVv) can prevent HBV-infection and associated liver diseases. However, concerns regarding its safety, particularly among patients with autoimmune diseases (i.e. SLE) were raised. Moreover, the aluminum adjuvant in HBVv was related to immune mediated adverse events. Therefore, we examined the effects of immunization with HBVv or alum on SLE-like disease in a murine model.NZBWF1 mice were immunized with HBVv (Engerix), or aluminum hydroxide (alum) or phosphate buffered saline (PBS) at 8 and 12 weeks of age. Mice were followed for weight, autoantibodies titers, blood counts, proteinuria, kidney histology, neurocognitive functions (novel object recognition, staircase, Y-maze and the forced swimming tests) and brain histology.Immunization with HBVv induced acceleration of kidney disease manifested by high anti-dsDNA antibodies (. p less than 0.01), early onset of proteinuria (. p less than 0.05), histological damage and deposition of HBs antigen in the kidney. Mice immunized with HBVv and/or alum had decreased cells counts mainly of the red cell lineage (. p less than 0.001), memory deficits (. p less than 0.01), and increased activated microglia in different areas of the brain compare with mice immunized with PBS. Anxiety-like behavior was more pronounced among mice immunized with alum.In conclusion, herein we report that immunization with the HBVv aggravated kidney disease in an animal model of SLE. Immunization with either HBVv or alum affected blood counts, neurocognitive functions and brain gliosis. Our data support the concept that different component of vaccines may be linked with immune and autoimmune mediated adverse events. © 2014 Elsevier Ltd. |
| format |
Artículo (Article) |
| author |
Agmon-Levin, Nancy Arango, María-Teresa Kivity, Shaye Katzav, Aviva Gilburd, Boris Blank, Miri Tomer, Nir Volkov, Alex Barshack, Iris Chapman, Joab Shoenfeld, Yehuda |
| author_facet |
Agmon-Levin, Nancy Arango, María-Teresa Kivity, Shaye Katzav, Aviva Gilburd, Boris Blank, Miri Tomer, Nir Volkov, Alex Barshack, Iris Chapman, Joab Shoenfeld, Yehuda |
| author_sort |
Agmon-Levin, Nancy |
| title |
Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model |
| title_short |
Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model |
| title_full |
Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model |
| title_fullStr |
Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model |
| title_full_unstemmed |
Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model |
| title_sort |
immunization with hepatitis b vaccine accelerates sle-like disease in a murine model |
| publisher |
Academic Press |
| publishDate |
2014 |
| url |
https://repository.urosario.edu.co/handle/10336/22257 https://doi.org/10.1016/j.jaut.2014.06.006 |
| _version_ |
1740172266317021184 |
| score |
12,131701 |