Passive transfer of narcolepsy: Anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice

"Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and cataplexy (a sudden weakening of posture muscle tone usually triggered by emotion) caused by the loss of orexin neurons in the hypothalamus. Autoimmune mechanisms are implicated in narcolepsy by increased frequenc...

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Detalles Bibliográficos
Autores Principales: Katzav, Aviva, Arango, Maria T., Kivity, Shaye, Tanaka, Susumu, Givaty, Gili, Agmon-Levin, Nancy, Honda, Makoto, Anaya, Juan-Manuel, Chapman, Joab, Shoenfeld, Yehuda
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2013
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22254
https://doi.org/10.1016/j.jaut.2013.06.010