Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity

"A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been pro...

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Autores Principales: Quintero, Olga L., Amador-Patarroyo, Manuel J., Montoya-Ortiz, Gladys, Rojas-Villarraga, Adriana, Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2012
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22252
https://doi.org/10.1016/j.jaut.2011.10.003
id ir-10336-22252
recordtype dspace
spelling ir-10336-222522021-01-21T08:20:02Z Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity Quintero, Olga L. Amador-Patarroyo, Manuel J. Montoya-Ortiz, Gladys Rojas-Villarraga, Adriana Anaya, Juan-Manuel Androgen Bromocriptine Estrogen Estrogen receptor Prolactin Antibody production Article Autoimmune disease Autoimmunity B lymphocyte activation Cd4 lymphocyte count Cd8+ t lymphocyte Cellular immunity Disease association Disease predisposition Genetic risk Hormonal regulation Human Humoral immunity Klinefelter syndrome Lymphoma Microchimerism Monocyte Monosomy x Multiple sclerosis Natural killer cell Neutrophil Onset age Pregnancy Pregnancy outcome Prevalence Priority journal Raynaud phenomenon Receptor binding Rheumatoid arthritis Sex difference Sjoegren syndrome Systemic lupus erythematosus Systemic sclerosis T lymphocyte activation Th1 cell Th2 cell X chromosome X chromosome inactivation Y chromosome Autoimmune diseases Autoimmunity Chimerism Chromosomes, human, x Female Hormones Humans Male Pregnancy Sex factors Autoimmune diseases Gender differences Sex hormones X chromosome "A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this predominance. These hypotheses have gained credence mostly because many of these diseases appear or fluctuate when there are hormonal changes such as in late adolescence and pregnancy. Differences in X chromosome characteristics between men and women with an AD have led researchers to think that the genetic background of this group of diseases also relates to the genetic determinants of gender. These hormonal changes as well as the genetic factors that could explain why women are more prone to develop ADs are herein reviewed. © 2011 Elsevier Ltd." 2012 2020-05-25T23:55:53Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 10959157 08968411 https://repository.urosario.edu.co/handle/10336/22252 https://doi.org/10.1016/j.jaut.2011.10.003 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Androgen
Bromocriptine
Estrogen
Estrogen receptor
Prolactin
Antibody production
Article
Autoimmune disease
Autoimmunity
B lymphocyte activation
Cd4 lymphocyte count
Cd8+ t lymphocyte
Cellular immunity
Disease association
Disease predisposition
Genetic risk
Hormonal regulation
Human
Humoral immunity
Klinefelter syndrome
Lymphoma
Microchimerism
Monocyte
Monosomy x
Multiple sclerosis
Natural killer cell
Neutrophil
Onset age
Pregnancy
Pregnancy outcome
Prevalence
Priority journal
Raynaud phenomenon
Receptor binding
Rheumatoid arthritis
Sex difference
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
T lymphocyte activation
Th1 cell
Th2 cell
X chromosome
X chromosome inactivation
Y chromosome
Autoimmune diseases
Autoimmunity
Chimerism
Chromosomes, human, x
Female
Hormones
Humans
Male
Pregnancy
Sex factors
Autoimmune diseases
Gender differences
Sex hormones
X chromosome
spellingShingle Androgen
Bromocriptine
Estrogen
Estrogen receptor
Prolactin
Antibody production
Article
Autoimmune disease
Autoimmunity
B lymphocyte activation
Cd4 lymphocyte count
Cd8+ t lymphocyte
Cellular immunity
Disease association
Disease predisposition
Genetic risk
Hormonal regulation
Human
Humoral immunity
Klinefelter syndrome
Lymphoma
Microchimerism
Monocyte
Monosomy x
Multiple sclerosis
Natural killer cell
Neutrophil
Onset age
Pregnancy
Pregnancy outcome
Prevalence
Priority journal
Raynaud phenomenon
Receptor binding
Rheumatoid arthritis
Sex difference
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
T lymphocyte activation
Th1 cell
Th2 cell
X chromosome
X chromosome inactivation
Y chromosome
Autoimmune diseases
Autoimmunity
Chimerism
Chromosomes, human, x
Female
Hormones
Humans
Male
Pregnancy
Sex factors
Autoimmune diseases
Gender differences
Sex hormones
X chromosome
Quintero, Olga L.
Amador-Patarroyo, Manuel J.
Montoya-Ortiz, Gladys
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity
description "A large number of autoimmune diseases (ADs) are more prevalent in women. The more frequent the AD and the later it appears, the more women are affected. Many ideas mainly based on hormonal and genetic factors that influence the autoimmune systems of females and males differently, have been proposed to explain this predominance. These hypotheses have gained credence mostly because many of these diseases appear or fluctuate when there are hormonal changes such as in late adolescence and pregnancy. Differences in X chromosome characteristics between men and women with an AD have led researchers to think that the genetic background of this group of diseases also relates to the genetic determinants of gender. These hormonal changes as well as the genetic factors that could explain why women are more prone to develop ADs are herein reviewed. © 2011 Elsevier Ltd."
format Artículo (Article)
author Quintero, Olga L.
Amador-Patarroyo, Manuel J.
Montoya-Ortiz, Gladys
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
author_facet Quintero, Olga L.
Amador-Patarroyo, Manuel J.
Montoya-Ortiz, Gladys
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
author_sort Quintero, Olga L.
title Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity
title_short Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity
title_full Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity
title_fullStr Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity
title_full_unstemmed Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity
title_sort autoimmune disease and gender: plausible mechanisms for the female predominance of autoimmunity
publishDate 2012
url https://repository.urosario.edu.co/handle/10336/22252
https://doi.org/10.1016/j.jaut.2011.10.003
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score 11,397477