Prevalence of hepatitis C serum antibody in autoimmune diseases
Objective: To evaluate the prevalence of serum antibodies against hepatitis C virus and other infectious agents in a large cohort of well-characterized patients with autoimmune diseases (AID). Methods: We utilized 1322 sera from patients with 18 different AID and 236 sera from healthy controls from...
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| Lenguaje: | Inglés (English) |
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2009
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| Acceso en línea: | https://repository.urosario.edu.co/handle/10336/22250 https://doi.org/10.1016/j.jaut.2009.02.017 |
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ir-10336-222502022-05-02T12:37:13Z Prevalence of hepatitis C serum antibody in autoimmune diseases Agmon-Levin, Nancy Ram, Maya Barzilai, Ori Porat-Katz, Bat sheva Parikman, Ronit Selmi, Carlo Gershwin, M. Eric Anaya, Juan-Manuel Youinou, Pierre Bizzaro, Nicola Tincani, Angela Tzioufas, Athanasios G. Cervera, Ricard Stojanovich, Ljudmila Martin, Javier Gonzalez-Gay, Miguel Angel Valentini, Gabriele Blank, Miri SanMarco, Marielle Rozman, Blaž Bombardieri, Stefano De Vita, Salvatore Shoenfeld, Yehuda Autoantibody Cytomegalovirus antibody Hepatitis b antibody Hepatitis c antibody Protozoon antibody Antibody detection Antiphospholipid syndrome Article Autoimmune disease Churg strauss syndrome Controlled study Cryoglobulinemia Diabetes mellitus Enteritis Giant cell arteritis Hashimoto disease Hepatitis c Hepatitis c virus Human Major clinical study Microscopic polyangiitis Multiple sclerosis Myositis Pemphigus vulgaris Prevalence Primary biliary cirrhosis Priority journal Rheumatoid arthritis Sjoegren syndrome Systemic lupus erythematosus Toxoplasma gondii Wegener granulomatosis Aged Autoantibodies Autoimmune diseases Female Hepatitis c Hepatitis c antibodies Humans Male Middle aged Prevalence Antiphospholipids syndrome Autoantibodies Autoimmune diseases Cryoglobulinemia Hepatitis-c Inflammatory bowel diseases Pemphigus vulgaris Thyroid autoimmune diseases Objective: To evaluate the prevalence of serum antibodies against hepatitis C virus and other infectious agents in a large cohort of well-characterized patients with autoimmune diseases (AID). Methods: We utilized 1322 sera from patients with 18 different AID and 236 sera from healthy controls from the same countries and with similar age and sex distribution. All sera were tested for the presence of serum anti-hepatitis C virus (HCV) antibodies as well as antibodies directed at other infectious agents and autoantibodies. Results: Anti-HCV antibody was detected in 115/1322 (8.7%) of patients with AID and 0.4% of matched healthy controls (P less than 0.0001). The prevalence of anti-HCV antibody was significantly higher in 7/18 different AID (i.e. cryoglobulinemia, mixed cryoglobulinemia pemphigus vulgaris, vasculitis, secondary anti-phospholipid syndrome, Hashimoto's thyroiditis, and inflammatory bowel disease) compared to controls. Patients with AID and serum anti-HCV positivity had an increased prevalence of antibodies against hepatitis B virus, Toxoplasma gondii and Cytomegalovirus as opposed to a lower frequency of serum autoantibodies. Conclusions: The enhanced prevalence of anti-HCV serum antibodies in AID may suggest a role for HCV in tolerance to breakdown, similarly to its established role in mixed cryoglobulinemia. This immune mediated effect does not rule out the role of other infectious agents. © 2009. 2009 2020-05-25T23:55:53Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 10959157 08968411 https://repository.urosario.edu.co/handle/10336/22250 https://doi.org/10.1016/j.jaut.2009.02.017 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
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EdocUR - Universidad del Rosario |
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DSpace |
| language |
Inglés (English) |
| topic |
Autoantibody Cytomegalovirus antibody Hepatitis b antibody Hepatitis c antibody Protozoon antibody Antibody detection Antiphospholipid syndrome Article Autoimmune disease Churg strauss syndrome Controlled study Cryoglobulinemia Diabetes mellitus Enteritis Giant cell arteritis Hashimoto disease Hepatitis c Hepatitis c virus Human Major clinical study Microscopic polyangiitis Multiple sclerosis Myositis Pemphigus vulgaris Prevalence Primary biliary cirrhosis Priority journal Rheumatoid arthritis Sjoegren syndrome Systemic lupus erythematosus Toxoplasma gondii Wegener granulomatosis Aged Autoantibodies Autoimmune diseases Female Hepatitis c Hepatitis c antibodies Humans Male Middle aged Prevalence Antiphospholipids syndrome Autoantibodies Autoimmune diseases Cryoglobulinemia Hepatitis-c Inflammatory bowel diseases Pemphigus vulgaris Thyroid autoimmune diseases |
| spellingShingle |
Autoantibody Cytomegalovirus antibody Hepatitis b antibody Hepatitis c antibody Protozoon antibody Antibody detection Antiphospholipid syndrome Article Autoimmune disease Churg strauss syndrome Controlled study Cryoglobulinemia Diabetes mellitus Enteritis Giant cell arteritis Hashimoto disease Hepatitis c Hepatitis c virus Human Major clinical study Microscopic polyangiitis Multiple sclerosis Myositis Pemphigus vulgaris Prevalence Primary biliary cirrhosis Priority journal Rheumatoid arthritis Sjoegren syndrome Systemic lupus erythematosus Toxoplasma gondii Wegener granulomatosis Aged Autoantibodies Autoimmune diseases Female Hepatitis c Hepatitis c antibodies Humans Male Middle aged Prevalence Antiphospholipids syndrome Autoantibodies Autoimmune diseases Cryoglobulinemia Hepatitis-c Inflammatory bowel diseases Pemphigus vulgaris Thyroid autoimmune diseases Agmon-Levin, Nancy Ram, Maya Barzilai, Ori Porat-Katz, Bat sheva Parikman, Ronit Selmi, Carlo Gershwin, M. Eric Anaya, Juan-Manuel Youinou, Pierre Bizzaro, Nicola Tincani, Angela Tzioufas, Athanasios G. Cervera, Ricard Stojanovich, Ljudmila Martin, Javier Gonzalez-Gay, Miguel Angel Valentini, Gabriele Blank, Miri SanMarco, Marielle Rozman, Blaž Bombardieri, Stefano De Vita, Salvatore Shoenfeld, Yehuda Prevalence of hepatitis C serum antibody in autoimmune diseases |
| description |
Objective: To evaluate the prevalence of serum antibodies against hepatitis C virus and other infectious agents in a large cohort of well-characterized patients with autoimmune diseases (AID). Methods: We utilized 1322 sera from patients with 18 different AID and 236 sera from healthy controls from the same countries and with similar age and sex distribution. All sera were tested for the presence of serum anti-hepatitis C virus (HCV) antibodies as well as antibodies directed at other infectious agents and autoantibodies. Results: Anti-HCV antibody was detected in 115/1322 (8.7%) of patients with AID and 0.4% of matched healthy controls (P less than 0.0001). The prevalence of anti-HCV antibody was significantly higher in 7/18 different AID (i.e. cryoglobulinemia, mixed cryoglobulinemia pemphigus vulgaris, vasculitis, secondary anti-phospholipid syndrome, Hashimoto's thyroiditis, and inflammatory bowel disease) compared to controls. Patients with AID and serum anti-HCV positivity had an increased prevalence of antibodies against hepatitis B virus, Toxoplasma gondii and Cytomegalovirus as opposed to a lower frequency of serum autoantibodies. Conclusions: The enhanced prevalence of anti-HCV serum antibodies in AID may suggest a role for HCV in tolerance to breakdown, similarly to its established role in mixed cryoglobulinemia. This immune mediated effect does not rule out the role of other infectious agents. © 2009. |
| format |
Artículo (Article) |
| author |
Agmon-Levin, Nancy Ram, Maya Barzilai, Ori Porat-Katz, Bat sheva Parikman, Ronit Selmi, Carlo Gershwin, M. Eric Anaya, Juan-Manuel Youinou, Pierre Bizzaro, Nicola Tincani, Angela Tzioufas, Athanasios G. Cervera, Ricard Stojanovich, Ljudmila Martin, Javier Gonzalez-Gay, Miguel Angel Valentini, Gabriele Blank, Miri SanMarco, Marielle Rozman, Blaž Bombardieri, Stefano De Vita, Salvatore Shoenfeld, Yehuda |
| author_facet |
Agmon-Levin, Nancy Ram, Maya Barzilai, Ori Porat-Katz, Bat sheva Parikman, Ronit Selmi, Carlo Gershwin, M. Eric Anaya, Juan-Manuel Youinou, Pierre Bizzaro, Nicola Tincani, Angela Tzioufas, Athanasios G. Cervera, Ricard Stojanovich, Ljudmila Martin, Javier Gonzalez-Gay, Miguel Angel Valentini, Gabriele Blank, Miri SanMarco, Marielle Rozman, Blaž Bombardieri, Stefano De Vita, Salvatore Shoenfeld, Yehuda |
| author_sort |
Agmon-Levin, Nancy |
| title |
Prevalence of hepatitis C serum antibody in autoimmune diseases |
| title_short |
Prevalence of hepatitis C serum antibody in autoimmune diseases |
| title_full |
Prevalence of hepatitis C serum antibody in autoimmune diseases |
| title_fullStr |
Prevalence of hepatitis C serum antibody in autoimmune diseases |
| title_full_unstemmed |
Prevalence of hepatitis C serum antibody in autoimmune diseases |
| title_sort |
prevalence of hepatitis c serum antibody in autoimmune diseases |
| publishDate |
2009 |
| url |
https://repository.urosario.edu.co/handle/10336/22250 https://doi.org/10.1016/j.jaut.2009.02.017 |
| _version_ |
1740172297061269504 |
| score |
12,131701 |