Prevalence of hepatitis C serum antibody in autoimmune diseases

Objective: To evaluate the prevalence of serum antibodies against hepatitis C virus and other infectious agents in a large cohort of well-characterized patients with autoimmune diseases (AID). Methods: We utilized 1322 sera from patients with 18 different AID and 236 sera from healthy controls from...

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Autores Principales: Agmon-Levin, Nancy, Ram, Maya, Barzilai, Ori, Porat-Katz, Bat sheva, Parikman, Ronit, Selmi, Carlo, Gershwin, M. Eric, Anaya, Juan-Manuel, Youinou, Pierre, Bizzaro, Nicola, Tincani, Angela, Tzioufas, Athanasios G., Cervera, Ricard, Stojanovich, Ljudmila, Martin, Javier, Gonzalez-Gay, Miguel Angel, Valentini, Gabriele, Blank, Miri, SanMarco, Marielle, Rozman, Blaž, Bombardieri, Stefano, De Vita, Salvatore, Shoenfeld, Yehuda
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2009
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22250
https://doi.org/10.1016/j.jaut.2009.02.017
id ir-10336-22250
recordtype dspace
spelling ir-10336-222502022-05-02T12:37:13Z Prevalence of hepatitis C serum antibody in autoimmune diseases Agmon-Levin, Nancy Ram, Maya Barzilai, Ori Porat-Katz, Bat sheva Parikman, Ronit Selmi, Carlo Gershwin, M. Eric Anaya, Juan-Manuel Youinou, Pierre Bizzaro, Nicola Tincani, Angela Tzioufas, Athanasios G. Cervera, Ricard Stojanovich, Ljudmila Martin, Javier Gonzalez-Gay, Miguel Angel Valentini, Gabriele Blank, Miri SanMarco, Marielle Rozman, Blaž Bombardieri, Stefano De Vita, Salvatore Shoenfeld, Yehuda Autoantibody Cytomegalovirus antibody Hepatitis b antibody Hepatitis c antibody Protozoon antibody Antibody detection Antiphospholipid syndrome Article Autoimmune disease Churg strauss syndrome Controlled study Cryoglobulinemia Diabetes mellitus Enteritis Giant cell arteritis Hashimoto disease Hepatitis c Hepatitis c virus Human Major clinical study Microscopic polyangiitis Multiple sclerosis Myositis Pemphigus vulgaris Prevalence Primary biliary cirrhosis Priority journal Rheumatoid arthritis Sjoegren syndrome Systemic lupus erythematosus Toxoplasma gondii Wegener granulomatosis Aged Autoantibodies Autoimmune diseases Female Hepatitis c Hepatitis c antibodies Humans Male Middle aged Prevalence Antiphospholipids syndrome Autoantibodies Autoimmune diseases Cryoglobulinemia Hepatitis-c Inflammatory bowel diseases Pemphigus vulgaris Thyroid autoimmune diseases Objective: To evaluate the prevalence of serum antibodies against hepatitis C virus and other infectious agents in a large cohort of well-characterized patients with autoimmune diseases (AID). Methods: We utilized 1322 sera from patients with 18 different AID and 236 sera from healthy controls from the same countries and with similar age and sex distribution. All sera were tested for the presence of serum anti-hepatitis C virus (HCV) antibodies as well as antibodies directed at other infectious agents and autoantibodies. Results: Anti-HCV antibody was detected in 115/1322 (8.7%) of patients with AID and 0.4% of matched healthy controls (P less than 0.0001). The prevalence of anti-HCV antibody was significantly higher in 7/18 different AID (i.e. cryoglobulinemia, mixed cryoglobulinemia pemphigus vulgaris, vasculitis, secondary anti-phospholipid syndrome, Hashimoto's thyroiditis, and inflammatory bowel disease) compared to controls. Patients with AID and serum anti-HCV positivity had an increased prevalence of antibodies against hepatitis B virus, Toxoplasma gondii and Cytomegalovirus as opposed to a lower frequency of serum autoantibodies. Conclusions: The enhanced prevalence of anti-HCV serum antibodies in AID may suggest a role for HCV in tolerance to breakdown, similarly to its established role in mixed cryoglobulinemia. This immune mediated effect does not rule out the role of other infectious agents. © 2009. 2009 2020-05-25T23:55:53Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 10959157 08968411 https://repository.urosario.edu.co/handle/10336/22250 https://doi.org/10.1016/j.jaut.2009.02.017 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Autoantibody
Cytomegalovirus antibody
Hepatitis b antibody
Hepatitis c antibody
Protozoon antibody
Antibody detection
Antiphospholipid syndrome
Article
Autoimmune disease
Churg strauss syndrome
Controlled study
Cryoglobulinemia
Diabetes mellitus
Enteritis
Giant cell arteritis
Hashimoto disease
Hepatitis c
Hepatitis c virus
Human
Major clinical study
Microscopic polyangiitis
Multiple sclerosis
Myositis
Pemphigus vulgaris
Prevalence
Primary biliary cirrhosis
Priority journal
Rheumatoid arthritis
Sjoegren syndrome
Systemic lupus erythematosus
Toxoplasma gondii
Wegener granulomatosis
Aged
Autoantibodies
Autoimmune diseases
Female
Hepatitis c
Hepatitis c antibodies
Humans
Male
Middle aged
Prevalence
Antiphospholipids syndrome
Autoantibodies
Autoimmune diseases
Cryoglobulinemia
Hepatitis-c
Inflammatory bowel diseases
Pemphigus vulgaris
Thyroid autoimmune diseases
spellingShingle Autoantibody
Cytomegalovirus antibody
Hepatitis b antibody
Hepatitis c antibody
Protozoon antibody
Antibody detection
Antiphospholipid syndrome
Article
Autoimmune disease
Churg strauss syndrome
Controlled study
Cryoglobulinemia
Diabetes mellitus
Enteritis
Giant cell arteritis
Hashimoto disease
Hepatitis c
Hepatitis c virus
Human
Major clinical study
Microscopic polyangiitis
Multiple sclerosis
Myositis
Pemphigus vulgaris
Prevalence
Primary biliary cirrhosis
Priority journal
Rheumatoid arthritis
Sjoegren syndrome
Systemic lupus erythematosus
Toxoplasma gondii
Wegener granulomatosis
Aged
Autoantibodies
Autoimmune diseases
Female
Hepatitis c
Hepatitis c antibodies
Humans
Male
Middle aged
Prevalence
Antiphospholipids syndrome
Autoantibodies
Autoimmune diseases
Cryoglobulinemia
Hepatitis-c
Inflammatory bowel diseases
Pemphigus vulgaris
Thyroid autoimmune diseases
Agmon-Levin, Nancy
Ram, Maya
Barzilai, Ori
Porat-Katz, Bat sheva
Parikman, Ronit
Selmi, Carlo
Gershwin, M. Eric
Anaya, Juan-Manuel
Youinou, Pierre
Bizzaro, Nicola
Tincani, Angela
Tzioufas, Athanasios G.
Cervera, Ricard
Stojanovich, Ljudmila
Martin, Javier
Gonzalez-Gay, Miguel Angel
Valentini, Gabriele
Blank, Miri
SanMarco, Marielle
Rozman, Blaž
Bombardieri, Stefano
De Vita, Salvatore
Shoenfeld, Yehuda
Prevalence of hepatitis C serum antibody in autoimmune diseases
description Objective: To evaluate the prevalence of serum antibodies against hepatitis C virus and other infectious agents in a large cohort of well-characterized patients with autoimmune diseases (AID). Methods: We utilized 1322 sera from patients with 18 different AID and 236 sera from healthy controls from the same countries and with similar age and sex distribution. All sera were tested for the presence of serum anti-hepatitis C virus (HCV) antibodies as well as antibodies directed at other infectious agents and autoantibodies. Results: Anti-HCV antibody was detected in 115/1322 (8.7%) of patients with AID and 0.4% of matched healthy controls (P less than 0.0001). The prevalence of anti-HCV antibody was significantly higher in 7/18 different AID (i.e. cryoglobulinemia, mixed cryoglobulinemia pemphigus vulgaris, vasculitis, secondary anti-phospholipid syndrome, Hashimoto's thyroiditis, and inflammatory bowel disease) compared to controls. Patients with AID and serum anti-HCV positivity had an increased prevalence of antibodies against hepatitis B virus, Toxoplasma gondii and Cytomegalovirus as opposed to a lower frequency of serum autoantibodies. Conclusions: The enhanced prevalence of anti-HCV serum antibodies in AID may suggest a role for HCV in tolerance to breakdown, similarly to its established role in mixed cryoglobulinemia. This immune mediated effect does not rule out the role of other infectious agents. © 2009.
format Artículo (Article)
author Agmon-Levin, Nancy
Ram, Maya
Barzilai, Ori
Porat-Katz, Bat sheva
Parikman, Ronit
Selmi, Carlo
Gershwin, M. Eric
Anaya, Juan-Manuel
Youinou, Pierre
Bizzaro, Nicola
Tincani, Angela
Tzioufas, Athanasios G.
Cervera, Ricard
Stojanovich, Ljudmila
Martin, Javier
Gonzalez-Gay, Miguel Angel
Valentini, Gabriele
Blank, Miri
SanMarco, Marielle
Rozman, Blaž
Bombardieri, Stefano
De Vita, Salvatore
Shoenfeld, Yehuda
author_facet Agmon-Levin, Nancy
Ram, Maya
Barzilai, Ori
Porat-Katz, Bat sheva
Parikman, Ronit
Selmi, Carlo
Gershwin, M. Eric
Anaya, Juan-Manuel
Youinou, Pierre
Bizzaro, Nicola
Tincani, Angela
Tzioufas, Athanasios G.
Cervera, Ricard
Stojanovich, Ljudmila
Martin, Javier
Gonzalez-Gay, Miguel Angel
Valentini, Gabriele
Blank, Miri
SanMarco, Marielle
Rozman, Blaž
Bombardieri, Stefano
De Vita, Salvatore
Shoenfeld, Yehuda
author_sort Agmon-Levin, Nancy
title Prevalence of hepatitis C serum antibody in autoimmune diseases
title_short Prevalence of hepatitis C serum antibody in autoimmune diseases
title_full Prevalence of hepatitis C serum antibody in autoimmune diseases
title_fullStr Prevalence of hepatitis C serum antibody in autoimmune diseases
title_full_unstemmed Prevalence of hepatitis C serum antibody in autoimmune diseases
title_sort prevalence of hepatitis c serum antibody in autoimmune diseases
publishDate 2009
url https://repository.urosario.edu.co/handle/10336/22250
https://doi.org/10.1016/j.jaut.2009.02.017
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score 12,111491