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Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without...

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Autores Principales:	Anaya, Juan-Manuel, Castiblanco J., Tobón G.J., García J., Abad V., Cuervo H., Velásquez A., Angel I.D., Vega P., Arango A.
Formato:	Artículo (Article)
Lenguaje:	Inglés (English)
Publicado:	2006
Materias:	Adolescent Article Autoimmune disease Child Confidence interval Controlled study Demography Family relation Female Genetic analysis Human Insulin dependent diabetes mellitus Major clinical study Male Pedigree Priority journal Questionnaire Thyroid disease Autoimmune diseases Humans Aggregation Autoimmunity Genetics Hypothyroidism Type 1 diabetes mellitus type 1 Diabetes mellitus
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/22247 https://doi.org/10.1016/j.jaut.2006.01.001

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recordtype	dspace
spelling	ir-10336-222472022-05-02T12:37:13Z Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus Anaya, Juan-Manuel Castiblanco J. Tobón G.J. García J. Abad V. Cuervo H. Velásquez A. Angel I.D. Vega P. Arango A. Adolescent Article Autoimmune disease Child Confidence interval Controlled study Demography Family relation Female Genetic analysis Human Insulin dependent diabetes mellitus Major clinical study Male Pedigree Priority journal Questionnaire Thyroid disease Autoimmune diseases Child Female Humans Male Pedigree Aggregation Autoimmunity Genetics Hypothyroidism Type 1 diabetes mellitus type 1 Diabetes mellitus We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. © 2006 Elsevier Ltd. All rights reserved. 2006 2020-05-25T23:55:52Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 10959157 08968411 https://repository.urosario.edu.co/handle/10336/22247 https://doi.org/10.1016/j.jaut.2006.01.001 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution	EdocUR - Universidad del Rosario
collection	DSpace
language	Inglés (English)
topic	Adolescent Article Autoimmune disease Child Confidence interval Controlled study Demography Family relation Female Genetic analysis Human Insulin dependent diabetes mellitus Major clinical study Male Pedigree Priority journal Questionnaire Thyroid disease Autoimmune diseases Child Female Humans Male Pedigree Aggregation Autoimmunity Genetics Hypothyroidism Type 1 diabetes mellitus type 1 Diabetes mellitus
spellingShingle	Adolescent Article Autoimmune disease Child Confidence interval Controlled study Demography Family relation Female Genetic analysis Human Insulin dependent diabetes mellitus Major clinical study Male Pedigree Priority journal Questionnaire Thyroid disease Autoimmune diseases Child Female Humans Male Pedigree Aggregation Autoimmunity Genetics Hypothyroidism Type 1 diabetes mellitus type 1 Diabetes mellitus Anaya, Juan-Manuel Castiblanco J. Tobón G.J. García J. Abad V. Cuervo H. Velásquez A. Angel I.D. Vega P. Arango A. Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
description	We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. © 2006 Elsevier Ltd. All rights reserved.
format	Artículo (Article)
author	Anaya, Juan-Manuel Castiblanco J. Tobón G.J. García J. Abad V. Cuervo H. Velásquez A. Angel I.D. Vega P. Arango A.
author_facet	Anaya, Juan-Manuel Castiblanco J. Tobón G.J. García J. Abad V. Cuervo H. Velásquez A. Angel I.D. Vega P. Arango A.
author_sort	Anaya, Juan-Manuel
title	Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
title_short	Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
title_full	Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
title_fullStr	Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
title_full_unstemmed	Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
title_sort	familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
publishDate	2006
url	https://repository.urosario.edu.co/handle/10336/22247 https://doi.org/10.1016/j.jaut.2006.01.001
_version_	1740172101113872384
score	12,131701

Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

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