Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease characterized by neurological symptoms and signs of progressive weakness, paresthesias, and sensory dysfunction. Other symptoms include reduced or absent tendon reflexes, cranial nerve involvement, autonomic symptoms,...

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Autores Principales: Rodríguez Y., Vatti N., Ramirez-Santana, Carolina, Chang C., Mancera-Páez O., Gershwin M.E., Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Academic Press 2019
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22243
https://doi.org/10.1016/j.jaut.2019.04.021
id ir-10336-22243
recordtype dspace
spelling ir-10336-222432022-05-02T12:37:16Z Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease Rodríguez Y. Vatti N. Ramirez-Santana, Carolina Chang C. Mancera-Páez O. Gershwin M.E. Anaya, Juan-Manuel Connexin 32 Contactin 1 Contactin associated protein 1 Corticosteroid derivative Cyclophosphamide Immunoglobulin Methotrexate Mycophenolate mofetil Myelin basic protein Myelin protein Neurofascin 155 Peripheral myelin protein 22 Rituximab Unclassified drug Adaptive immunity Ataxia Bartonella henselae Chronic inflammatory demyelinating polyneuropathy Clinical feature Clinical practice Cytomegalovirus Environmental factor Epstein barr virus Hepatitis b virus Hepatitis c virus Heredity Human Human immunodeficiency virus Humoral immunity Immunosuppressive treatment Mycoplasma pneumoniae Nerve conduction Neuropathic pain Paresthesia Pathogenesis Plasma exchange Priority journal Ranvier node Reflex disorder Review Sensory dysfunction Tendon reflex Weakness Autoimmune disease Autoimmune ecology Autoimmune tautology Chronic inflammatory demyelinating polyradiculoneuropathy Guillain-barré syndrome Molecular mimicry Polyautoimmunity Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease characterized by neurological symptoms and signs of progressive weakness, paresthesias, and sensory dysfunction. Other symptoms include reduced or absent tendon reflexes, cranial nerve involvement, autonomic symptoms, ataxia, and neuropathic pain. Unlike other autoimmune diseases, CIDP generally affects older individuals and has a male predominance. The onset is generally insidious and can take up to 8 weeks with a relapsing-recovery pattern. Like all autoimmune diseases, the etiology is multifactorial, with both genetic and environmental factors contributing to it. Case reports of CIDP have found associations with multiple pathogenic organisms including Hepatitis B and C viruses, Bartonella henselae, Mycoplasma pneumoniae, Human immunodeficiency virus, Cytomegalovirus and Epstein-Barr virus. Possible antigenic self-targets include myelin protein 0, myelin protein 2, peripheral myelin protein 22, Connexin 32, and myelin basic protein. Antibodies targeting the Ranvier node proteins such as contactin-1, contactin-associated protein 1, and neurofascin 155 have been described. CIDP is treated with rehabilitation and pharmacological modalities. Pharmacological treatments target autoimmune dysfunction and include corticosteroids, intravenous immunoglobulin, subcutaneous immunoglobulin, plasma exchange, immunosuppressive and immunomodulatory agents such as methotrexate, cyclophosphamide, rituximab, and mycophenolate mofetil. Although there are few observational studies and randomized clinical trials with limited evidence supporting the use of immunosuppressive drugs, they are widely used in clinical practice. A comprehensive review of CIDP is presented herein in light of the autoimmune tautology. © 2019 Elsevier Ltd 2019 2020-05-25T23:55:51Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 10959157 08968411 https://repository.urosario.edu.co/handle/10336/22243 https://doi.org/10.1016/j.jaut.2019.04.021 eng info:eu-repo/semantics/openAccess application/pdf Academic Press instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Connexin 32
Contactin 1
Contactin associated protein 1
Corticosteroid derivative
Cyclophosphamide
Immunoglobulin
Methotrexate
Mycophenolate mofetil
Myelin basic protein
Myelin protein
Neurofascin 155
Peripheral myelin protein 22
Rituximab
Unclassified drug
Adaptive immunity
Ataxia
Bartonella henselae
Chronic inflammatory demyelinating polyneuropathy
Clinical feature
Clinical practice
Cytomegalovirus
Environmental factor
Epstein barr virus
Hepatitis b virus
Hepatitis c virus
Heredity
Human
Human immunodeficiency virus
Humoral immunity
Immunosuppressive treatment
Mycoplasma pneumoniae
Nerve conduction
Neuropathic pain
Paresthesia
Pathogenesis
Plasma exchange
Priority journal
Ranvier node
Reflex disorder
Review
Sensory dysfunction
Tendon reflex
Weakness
Autoimmune disease
Autoimmune ecology
Autoimmune tautology
Chronic inflammatory demyelinating polyradiculoneuropathy
Guillain-barré syndrome
Molecular mimicry
Polyautoimmunity
spellingShingle Connexin 32
Contactin 1
Contactin associated protein 1
Corticosteroid derivative
Cyclophosphamide
Immunoglobulin
Methotrexate
Mycophenolate mofetil
Myelin basic protein
Myelin protein
Neurofascin 155
Peripheral myelin protein 22
Rituximab
Unclassified drug
Adaptive immunity
Ataxia
Bartonella henselae
Chronic inflammatory demyelinating polyneuropathy
Clinical feature
Clinical practice
Cytomegalovirus
Environmental factor
Epstein barr virus
Hepatitis b virus
Hepatitis c virus
Heredity
Human
Human immunodeficiency virus
Humoral immunity
Immunosuppressive treatment
Mycoplasma pneumoniae
Nerve conduction
Neuropathic pain
Paresthesia
Pathogenesis
Plasma exchange
Priority journal
Ranvier node
Reflex disorder
Review
Sensory dysfunction
Tendon reflex
Weakness
Autoimmune disease
Autoimmune ecology
Autoimmune tautology
Chronic inflammatory demyelinating polyradiculoneuropathy
Guillain-barré syndrome
Molecular mimicry
Polyautoimmunity
Rodríguez Y.
Vatti N.
Ramirez-Santana, Carolina
Chang C.
Mancera-Páez O.
Gershwin M.E.
Anaya, Juan-Manuel
Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease
description Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease characterized by neurological symptoms and signs of progressive weakness, paresthesias, and sensory dysfunction. Other symptoms include reduced or absent tendon reflexes, cranial nerve involvement, autonomic symptoms, ataxia, and neuropathic pain. Unlike other autoimmune diseases, CIDP generally affects older individuals and has a male predominance. The onset is generally insidious and can take up to 8 weeks with a relapsing-recovery pattern. Like all autoimmune diseases, the etiology is multifactorial, with both genetic and environmental factors contributing to it. Case reports of CIDP have found associations with multiple pathogenic organisms including Hepatitis B and C viruses, Bartonella henselae, Mycoplasma pneumoniae, Human immunodeficiency virus, Cytomegalovirus and Epstein-Barr virus. Possible antigenic self-targets include myelin protein 0, myelin protein 2, peripheral myelin protein 22, Connexin 32, and myelin basic protein. Antibodies targeting the Ranvier node proteins such as contactin-1, contactin-associated protein 1, and neurofascin 155 have been described. CIDP is treated with rehabilitation and pharmacological modalities. Pharmacological treatments target autoimmune dysfunction and include corticosteroids, intravenous immunoglobulin, subcutaneous immunoglobulin, plasma exchange, immunosuppressive and immunomodulatory agents such as methotrexate, cyclophosphamide, rituximab, and mycophenolate mofetil. Although there are few observational studies and randomized clinical trials with limited evidence supporting the use of immunosuppressive drugs, they are widely used in clinical practice. A comprehensive review of CIDP is presented herein in light of the autoimmune tautology. © 2019 Elsevier Ltd
format Artículo (Article)
author Rodríguez Y.
Vatti N.
Ramirez-Santana, Carolina
Chang C.
Mancera-Páez O.
Gershwin M.E.
Anaya, Juan-Manuel
author_facet Rodríguez Y.
Vatti N.
Ramirez-Santana, Carolina
Chang C.
Mancera-Páez O.
Gershwin M.E.
Anaya, Juan-Manuel
author_sort Rodríguez Y.
title Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease
title_short Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease
title_full Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease
title_fullStr Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease
title_full_unstemmed Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease
title_sort chronic inflammatory demyelinating polyneuropathy as an autoimmune disease
publisher Academic Press
publishDate 2019
url https://repository.urosario.edu.co/handle/10336/22243
https://doi.org/10.1016/j.jaut.2019.04.021
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score 12,131701