ADHD Endophenotypes in Caribbean Families

Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The geneti...

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Autores Principales: Cervantes-Henríquez, M L, Acosta-López, J E, Martínez-Banfi, M L, Vélez, J I, Mejía-Segura, E, Lozano-Gutiérrez, S G, Sánchez-Rojas, M, Zurbarán, M A, Zurek, E E, Arcos-Burgos, M, Pineda, D A, Puentes-Rozo, P J
Formato: Contribución a periódico (Contribution To Periodical)
Lenguaje:Inglés (English)
Publicado: SAGE Publications Inc. 2018
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22241
https://doi.org/10.1177/1087054718763741
id ir-10336-22241
recordtype dspace
spelling ir-10336-222412022-05-02T12:37:18Z ADHD Endophenotypes in Caribbean Families Cervantes-Henríquez, M L Acosta-López, J E Martínez-Banfi, M L Vélez, J I Mejía-Segura, E Lozano-Gutiérrez, S G Sánchez-Rojas, M Zurbarán, M A Zurek, E E Arcos-Burgos, M Pineda, D A Puentes-Rozo, P J Adhd Attention Endophenotypes Genetics Heritability Memory Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD. © 2018, The Author(s) 2018. 2018 2020-05-25T23:55:51Z info:eu-repo/semantics/contributionToPeriodical info:eu-repo/semantics/publishedVersion 10870547 https://repository.urosario.edu.co/handle/10336/22241 https://doi.org/10.1177/1087054718763741 eng info:eu-repo/semantics/openAccess application/pdf SAGE Publications Inc. instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Adhd
Attention
Endophenotypes
Genetics
Heritability
Memory
spellingShingle Adhd
Attention
Endophenotypes
Genetics
Heritability
Memory
Cervantes-Henríquez, M L
Acosta-López, J E
Martínez-Banfi, M L
Vélez, J I
Mejía-Segura, E
Lozano-Gutiérrez, S G
Sánchez-Rojas, M
Zurbarán, M A
Zurek, E E
Arcos-Burgos, M
Pineda, D A
Puentes-Rozo, P J
ADHD Endophenotypes in Caribbean Families
description Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD. © 2018, The Author(s) 2018.
format Contribución a periódico (Contribution To Periodical)
author Cervantes-Henríquez, M L
Acosta-López, J E
Martínez-Banfi, M L
Vélez, J I
Mejía-Segura, E
Lozano-Gutiérrez, S G
Sánchez-Rojas, M
Zurbarán, M A
Zurek, E E
Arcos-Burgos, M
Pineda, D A
Puentes-Rozo, P J
author_facet Cervantes-Henríquez, M L
Acosta-López, J E
Martínez-Banfi, M L
Vélez, J I
Mejía-Segura, E
Lozano-Gutiérrez, S G
Sánchez-Rojas, M
Zurbarán, M A
Zurek, E E
Arcos-Burgos, M
Pineda, D A
Puentes-Rozo, P J
author_sort Cervantes-Henríquez, M L
title ADHD Endophenotypes in Caribbean Families
title_short ADHD Endophenotypes in Caribbean Families
title_full ADHD Endophenotypes in Caribbean Families
title_fullStr ADHD Endophenotypes in Caribbean Families
title_full_unstemmed ADHD Endophenotypes in Caribbean Families
title_sort adhd endophenotypes in caribbean families
publisher SAGE Publications Inc.
publishDate 2018
url https://repository.urosario.edu.co/handle/10336/22241
https://doi.org/10.1177/1087054718763741
_version_ 1740172771852288000
score 12,131701