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Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

Objectives: T-705, also known as favipiravir, is a small-molecule inhibitor that is currently in clinical development for the treatment of influenza virus infections. This molecule also inhibits the replication of a broad spectrum of other RNA viruses. The objective of this study was to investigate...

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Detalles Bibliográficos
Autores Principales: Delang, Leen, Guerrero, Nidya Segura, Tas, Ali, Quérat, Gilles, Pastorino, Boris, Froeyen, Mathy, Dallmeier, Kai, Jochmans, Dirk, Herdewijn, Piet, Bello, Felio, Snijder, Eric J., de Lamballerie, Xavier, Martina, Byron, Neyts, Johan, van Hemert, Martijn J., Leyssen, Pieter
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: Oxford University Press 2014
Materias:
Antivirus agent
Chloroquine
Favipiravir
Lysine
Nonstructural protein
Rna directed rna polymerase
T 1005
Unclassified drug
Viral protein
Amide
Pyrazine derivative
Virus protein
Alphavirus
Animal cell
Animal experiment
Animal model
Antiviral activity
Article
Barmah forest virus
Chikungunya
Chikungunya virus
Controlled study
Drug efficacy
Eastern equine encephalitis virus
Ec50
Genotype
Mouse
Mutation
Nonhuman
O nyong nyong virus
Phenotype
Reverse engineering
Ross river virus
Semliki forest virus
Sindbis virus
Venezuelan equine encephalitis virus
Virus cell interaction
Virus genome
Virus infectivity
Virus isolation
Virus load
Virus replication
Virus strain
Animal
Antiviral resistance
Cell line
Chemistry
Chikungunya fever
Cytopathogenic effect
Disease model
Dose response
Drug effects
Genetics
Microbial sensitivity test
Reproducibility
Virology
Amides
Animals
Antiviral agents
Mice
Microbial sensitivity tests
Pyrazines
Reproducibility of results
Viral nonstructural proteins
Nsp4
Polymerase
viral
animal
drug
Disease models
Dose-response relationship
Drug resistance
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22227
https://doi.org/10.1093/jac/dku209

Internet

https://repository.urosario.edu.co/handle/10336/22227
https://doi.org/10.1093/jac/dku209

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