Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Po...
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ir-10336-222102022-05-02T12:37:13Z Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis Diaz F.J. Rojas-Villarraga A. Salazar J.C. Iglesias-Gamarra A. Mantilla R.D. Anaya, Juan-Manuel Cyclic citrullinated peptide antibody Article Disease association Female Gene sequence Human Major clinical study Male Onset age Rheumatoid arthritis Risk factor Adult Age of onset Colombia Female Hla-dr antigens Humans Male Middle aged Regression analysis Retrospective studies Risk factors Age Anti-ccp antibodies Hla-drb1 Rheumatoid arthritis Rheumatoid factor Smoking Tnf-308 a allele single nucleotide rheumatoid cyclic anti-idiotypic Antibodies Arthritis Peptides Polymorphism Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. © 2010 Société française de rhumatologie. 2011 2020-05-25T23:55:46Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1297319X https://repository.urosario.edu.co/handle/10336/22210 https://doi.org/10.1016/j.jbspin.2010.07.014 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario |
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EdocUR - Universidad del Rosario |
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Inglés (English) |
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Cyclic citrullinated peptide antibody Article Disease association Female Gene sequence Human Major clinical study Male Onset age Rheumatoid arthritis Risk factor Adult Age of onset Colombia Female Hla-dr antigens Humans Male Middle aged Regression analysis Retrospective studies Risk factors Age Anti-ccp antibodies Hla-drb1 Rheumatoid arthritis Rheumatoid factor Smoking Tnf-308 a allele single nucleotide rheumatoid cyclic anti-idiotypic Antibodies Arthritis Peptides Polymorphism |
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Cyclic citrullinated peptide antibody Article Disease association Female Gene sequence Human Major clinical study Male Onset age Rheumatoid arthritis Risk factor Adult Age of onset Colombia Female Hla-dr antigens Humans Male Middle aged Regression analysis Retrospective studies Risk factors Age Anti-ccp antibodies Hla-drb1 Rheumatoid arthritis Rheumatoid factor Smoking Tnf-308 a allele single nucleotide rheumatoid cyclic anti-idiotypic Antibodies Arthritis Peptides Polymorphism Diaz F.J. Rojas-Villarraga A. Salazar J.C. Iglesias-Gamarra A. Mantilla R.D. Anaya, Juan-Manuel Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis |
description |
Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. © 2010 Société française de rhumatologie. |
format |
Artículo (Article) |
author |
Diaz F.J. Rojas-Villarraga A. Salazar J.C. Iglesias-Gamarra A. Mantilla R.D. Anaya, Juan-Manuel |
author_facet |
Diaz F.J. Rojas-Villarraga A. Salazar J.C. Iglesias-Gamarra A. Mantilla R.D. Anaya, Juan-Manuel |
author_sort |
Diaz F.J. |
title |
Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis |
title_short |
Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis |
title_full |
Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis |
title_fullStr |
Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis |
title_full_unstemmed |
Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis |
title_sort |
anti-ccp antibodies are associated with early age at onset in patients with rheumatoid arthritis |
publishDate |
2011 |
url |
https://repository.urosario.edu.co/handle/10336/22210 https://doi.org/10.1016/j.jbspin.2010.07.014 |
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1740172809074638848 |
score |
12,131701 |