Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis

Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Po...

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Autores Principales: Diaz F.J., Rojas-Villarraga A., Salazar J.C., Iglesias-Gamarra A., Mantilla R.D., Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2011
Materias:
Age
Acceso en línea:https://repository.urosario.edu.co/handle/10336/22210
https://doi.org/10.1016/j.jbspin.2010.07.014
id ir-10336-22210
recordtype dspace
spelling ir-10336-222102022-05-02T12:37:13Z Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis Diaz F.J. Rojas-Villarraga A. Salazar J.C. Iglesias-Gamarra A. Mantilla R.D. Anaya, Juan-Manuel Cyclic citrullinated peptide antibody Article Disease association Female Gene sequence Human Major clinical study Male Onset age Rheumatoid arthritis Risk factor Adult Age of onset Colombia Female Hla-dr antigens Humans Male Middle aged Regression analysis Retrospective studies Risk factors Age Anti-ccp antibodies Hla-drb1 Rheumatoid arthritis Rheumatoid factor Smoking Tnf-308 a allele single nucleotide rheumatoid cyclic anti-idiotypic Antibodies Arthritis Peptides Polymorphism Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. © 2010 Société française de rhumatologie. 2011 2020-05-25T23:55:46Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1297319X https://repository.urosario.edu.co/handle/10336/22210 https://doi.org/10.1016/j.jbspin.2010.07.014 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Cyclic citrullinated peptide antibody
Article
Disease association
Female
Gene sequence
Human
Major clinical study
Male
Onset age
Rheumatoid arthritis
Risk factor
Adult
Age of onset
Colombia
Female
Hla-dr antigens
Humans
Male
Middle aged
Regression analysis
Retrospective studies
Risk factors
Age
Anti-ccp antibodies
Hla-drb1
Rheumatoid arthritis
Rheumatoid factor
Smoking
Tnf-308 a allele
single nucleotide
rheumatoid
cyclic
anti-idiotypic
Antibodies
Arthritis
Peptides
Polymorphism
spellingShingle Cyclic citrullinated peptide antibody
Article
Disease association
Female
Gene sequence
Human
Major clinical study
Male
Onset age
Rheumatoid arthritis
Risk factor
Adult
Age of onset
Colombia
Female
Hla-dr antigens
Humans
Male
Middle aged
Regression analysis
Retrospective studies
Risk factors
Age
Anti-ccp antibodies
Hla-drb1
Rheumatoid arthritis
Rheumatoid factor
Smoking
Tnf-308 a allele
single nucleotide
rheumatoid
cyclic
anti-idiotypic
Antibodies
Arthritis
Peptides
Polymorphism
Diaz F.J.
Rojas-Villarraga A.
Salazar J.C.
Iglesias-Gamarra A.
Mantilla R.D.
Anaya, Juan-Manuel
Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
description Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. © 2010 Société française de rhumatologie.
format Artículo (Article)
author Diaz F.J.
Rojas-Villarraga A.
Salazar J.C.
Iglesias-Gamarra A.
Mantilla R.D.
Anaya, Juan-Manuel
author_facet Diaz F.J.
Rojas-Villarraga A.
Salazar J.C.
Iglesias-Gamarra A.
Mantilla R.D.
Anaya, Juan-Manuel
author_sort Diaz F.J.
title Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
title_short Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
title_full Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
title_fullStr Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
title_full_unstemmed Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
title_sort anti-ccp antibodies are associated with early age at onset in patients with rheumatoid arthritis
publishDate 2011
url https://repository.urosario.edu.co/handle/10336/22210
https://doi.org/10.1016/j.jbspin.2010.07.014
_version_ 1740172809074638848
score 12,131701