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The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients

Objective The aim was to determine the prevalence of adverse drug reactions (ADRs) in hospitalized patients in a university hospital. Methods ADRs were identified by two evaluators, who reviewed the clinical histories of all patients admitted between 24 April and 24 May 2006. Patients with suspected...

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Autores Principales:	Calderon-Ospina, Carlos-Alberto, Bustamante?Rojas, Carlos
Formato:	Artículo (Article)
Lenguaje:	Inglés (English)
Publicado:	2010
Materias:	Antiinfective agent Adult Adverse drug reaction Aged Article Autonomic neuropathy Comorbidity Controlled study Disease classification Disease predisposition Dose time susceptibility classification Female Hospital patient Human Major clinical study Male Prevalence Priority journal Risk factor University hospital World health organization Adverse drug reaction reporting systems Age factors Colombia Cross-sectional studies Drug interactions Humans Middle aged Pharmaceutical preparations Risk factors Time factors Adverse effects Drug utilization Hospitalization Internal medicine Pharmacoepidemiology Postmarketing Product surveillance drug university Dose-response relationship Hospitals
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/22143 https://doi.org/10.1111/j.2042-7174.2010.00039.x

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spelling	ir-10336-221432022-05-02T12:37:13Z The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients Calderon-Ospina, Carlos-Alberto Bustamante?Rojas, Carlos Antiinfective agent Adult Adverse drug reaction Aged Article Autonomic neuropathy Comorbidity Controlled study Disease classification Disease predisposition Dose time susceptibility classification Female Hospital patient Human Major clinical study Male Prevalence Priority journal Risk factor University hospital World health organization Adverse drug reaction reporting systems Age factors Aged Colombia Comorbidity Cross-sectional studies Drug interactions Female Humans Male Middle aged Pharmaceutical preparations Risk factors Time factors Adverse effects Drug utilization Hospitalization Internal medicine Pharmacoepidemiology Postmarketing Product surveillance drug university Dose-response relationship Hospitals Objective The aim was to determine the prevalence of adverse drug reactions (ADRs) in hospitalized patients in a university hospital. Methods ADRs were identified by two evaluators, who reviewed the clinical histories of all patients admitted between 24 April and 24 May 2006. Patients with suspected ADRs were contacted. Three different investigators evaluated causality, the degree of preventability, and the mechanism producing the ADR. Causality was assessed using the scale proposed by the World Health Organization (WHO), and preventability was assessed using the modified Schumock and Thornton criteria. Key findings There were 32 ADRs in 104 hospitalized patients. Effects on the autonomic nervous system were the most common (13%) and the drugs most frequently implicated were systemic antimicrobial drugs (19%). Fifty-four per cent of the ADRs were classified as possible. Using the Dose, Time and Susceptibility (DoTS) classification, 77% of the ADRs were classified as being of collateral dose-responsiveness (i.e. they occurred within the range of therapeutic doses), and 65% were classified as intermediate reactions. The susceptibility factors associated most frequently with ADRs were comorbidities (i.e. the presence of diseases that were considered as risk factors to developing an ADR; 36%), age (26%) and exogenous factors (i.e. the presence of drug interactions that were involved in the occurrence of ADRs; 17%). Fifty per cent of the ADRs could have been prevented. Conclusions ADRs are very frequent in hospitalized patients and a significant proportion of them is preventable. The DoTS classification allowed complete evaluation of the types of ADR encountered. We are currently carrying out a much larger prospective study. © 2010 Royal Pharmaceutical Society of Great Britain. 2010 2020-05-25T23:55:36Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 9617671 https://repository.urosario.edu.co/handle/10336/22143 https://doi.org/10.1111/j.2042-7174.2010.00039.x eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution	EdocUR - Universidad del Rosario
collection	DSpace
language	Inglés (English)
topic	Antiinfective agent Adult Adverse drug reaction Aged Article Autonomic neuropathy Comorbidity Controlled study Disease classification Disease predisposition Dose time susceptibility classification Female Hospital patient Human Major clinical study Male Prevalence Priority journal Risk factor University hospital World health organization Adverse drug reaction reporting systems Age factors Aged Colombia Comorbidity Cross-sectional studies Drug interactions Female Humans Male Middle aged Pharmaceutical preparations Risk factors Time factors Adverse effects Drug utilization Hospitalization Internal medicine Pharmacoepidemiology Postmarketing Product surveillance drug university Dose-response relationship Hospitals
spellingShingle	Antiinfective agent Adult Adverse drug reaction Aged Article Autonomic neuropathy Comorbidity Controlled study Disease classification Disease predisposition Dose time susceptibility classification Female Hospital patient Human Major clinical study Male Prevalence Priority journal Risk factor University hospital World health organization Adverse drug reaction reporting systems Age factors Aged Colombia Comorbidity Cross-sectional studies Drug interactions Female Humans Male Middle aged Pharmaceutical preparations Risk factors Time factors Adverse effects Drug utilization Hospitalization Internal medicine Pharmacoepidemiology Postmarketing Product surveillance drug university Dose-response relationship Hospitals Calderon-Ospina, Carlos-Alberto Bustamante?Rojas, Carlos The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients
description	Objective The aim was to determine the prevalence of adverse drug reactions (ADRs) in hospitalized patients in a university hospital. Methods ADRs were identified by two evaluators, who reviewed the clinical histories of all patients admitted between 24 April and 24 May 2006. Patients with suspected ADRs were contacted. Three different investigators evaluated causality, the degree of preventability, and the mechanism producing the ADR. Causality was assessed using the scale proposed by the World Health Organization (WHO), and preventability was assessed using the modified Schumock and Thornton criteria. Key findings There were 32 ADRs in 104 hospitalized patients. Effects on the autonomic nervous system were the most common (13%) and the drugs most frequently implicated were systemic antimicrobial drugs (19%). Fifty-four per cent of the ADRs were classified as possible. Using the Dose, Time and Susceptibility (DoTS) classification, 77% of the ADRs were classified as being of collateral dose-responsiveness (i.e. they occurred within the range of therapeutic doses), and 65% were classified as intermediate reactions. The susceptibility factors associated most frequently with ADRs were comorbidities (i.e. the presence of diseases that were considered as risk factors to developing an ADR; 36%), age (26%) and exogenous factors (i.e. the presence of drug interactions that were involved in the occurrence of ADRs; 17%). Fifty per cent of the ADRs could have been prevented. Conclusions ADRs are very frequent in hospitalized patients and a significant proportion of them is preventable. The DoTS classification allowed complete evaluation of the types of ADR encountered. We are currently carrying out a much larger prospective study. © 2010 Royal Pharmaceutical Society of Great Britain.
format	Artículo (Article)
author	Calderon-Ospina, Carlos-Alberto Bustamante?Rojas, Carlos
author_facet	Calderon-Ospina, Carlos-Alberto Bustamante?Rojas, Carlos
author_sort	Calderon-Ospina, Carlos-Alberto
title	The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients
title_short	The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients
title_full	The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients
title_fullStr	The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients
title_full_unstemmed	The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients
title_sort	dots classification is a useful way to classify adverse drug reactions: a preliminary study in hospitalized patients
publishDate	2010
url	https://repository.urosario.edu.co/handle/10336/22143 https://doi.org/10.1111/j.2042-7174.2010.00039.x
_version_	1740173007205171200
score	12,131701

The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients

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