The dual role of senescence in Tumorigenesis

Senescence was rendered a tumor suppressor mechanism based on the observation of its protective effect against cancer in young organisms under conditions of oncogene activation or inactivation of tumor suppressor genes. In addition to this beneficial effect, senescence has been deemed to have age-as...

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Autores Principales: Chuaire-Noack, Lilian, Sanchez-Corredor, Magda-Carolina, Ramírez-Clavijo, Sandra
Formato: Revisión (Review)
Lenguaje:Inglés (English)
Publicado: 2010
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/21898
https://doi.org/10.4067/S0717-95022010000100006
id ir-10336-21898
recordtype dspace
spelling ir-10336-218982020-05-13T19:49:48Z The dual role of senescence in Tumorigenesis Papel dual de la senescencia en la tumorigénesis Chuaire-Noack, Lilian Sanchez-Corredor, Magda-Carolina Ramírez-Clavijo, Sandra Enfermedades Senescence Cancer Antagonistic pleiotropism Senescence was rendered a tumor suppressor mechanism based on the observation of its protective effect against cancer in young organisms under conditions of oncogene activation or inactivation of tumor suppressor genes. In addition to this beneficial effect, senescence has been deemed to have age-associated deleterious effects because, apparently, senescence not only recapitulates aging and therefore loss of function and tissue regeneration capacity, but can also induce preneoplastic changes in adjacent stromal cells, provoke degenerative diseases or induce the production of tumor cell growth promoting factors. For that reason, senescence has become an attractive therapeutic target against cancer. This paper reviews some of the latest findings on the role of senescence in the malignant progression and analyzes them in relation to the concept of antagonistic pleiotropism, as well as its possible use as a therapeutic target against cancer. 2010 2020-05-07T17:51:25Z info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion 0717-9367 https://repository.urosario.edu.co/handle/10336/21898 https://doi.org/10.4067/S0717-95022010000100006 eng info:eu-repo/semantics/openAccess application/pdf
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Enfermedades
Senescence
Cancer
Antagonistic pleiotropism
spellingShingle Enfermedades
Senescence
Cancer
Antagonistic pleiotropism
Chuaire-Noack, Lilian
Sanchez-Corredor, Magda-Carolina
Ramírez-Clavijo, Sandra
The dual role of senescence in Tumorigenesis
description Senescence was rendered a tumor suppressor mechanism based on the observation of its protective effect against cancer in young organisms under conditions of oncogene activation or inactivation of tumor suppressor genes. In addition to this beneficial effect, senescence has been deemed to have age-associated deleterious effects because, apparently, senescence not only recapitulates aging and therefore loss of function and tissue regeneration capacity, but can also induce preneoplastic changes in adjacent stromal cells, provoke degenerative diseases or induce the production of tumor cell growth promoting factors. For that reason, senescence has become an attractive therapeutic target against cancer. This paper reviews some of the latest findings on the role of senescence in the malignant progression and analyzes them in relation to the concept of antagonistic pleiotropism, as well as its possible use as a therapeutic target against cancer.
format Revisión (Review)
author Chuaire-Noack, Lilian
Sanchez-Corredor, Magda-Carolina
Ramírez-Clavijo, Sandra
author_facet Chuaire-Noack, Lilian
Sanchez-Corredor, Magda-Carolina
Ramírez-Clavijo, Sandra
author_sort Chuaire-Noack, Lilian
title The dual role of senescence in Tumorigenesis
title_short The dual role of senescence in Tumorigenesis
title_full The dual role of senescence in Tumorigenesis
title_fullStr The dual role of senescence in Tumorigenesis
title_full_unstemmed The dual role of senescence in Tumorigenesis
title_sort dual role of senescence in tumorigenesis
publishDate 2010
url https://repository.urosario.edu.co/handle/10336/21898
https://doi.org/10.4067/S0717-95022010000100006
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score 11,828437