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Anti-group A streptococcal vaccine epitope : Structure, stability, and its ability to interact with HLA class II molecules

Streptococcus pyogenes infections remain a health problem in several countries due to poststreptococcal sequelae. We developed a vaccine epitope (StreptInCor) composed of 55 amino acids residues of the C-terminal portion of the M protein that encompasses both T and B cell protective epitopes. The nu...

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Detalles Bibliográficos
Autores Principales: Guilherme, Luiza, Alba, Martha patricia, Moraes Ferreira, Frederico, Emiko Oshiro, Sandra, Higa, Fabio, Patarroyo, Manuel-Elkin, Kalil, Jorge
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2011
Materias:
Ciencias médicas, Medicina
Química & ciencias afines
controlled study
human
Humans
Amino acid sequence
B cells
Class II
Helical structures
Helix residues
Humoral immune response
Micro-domains
Microdomain
Potential sites
Streptococcus pyogenes
T-cell epitopes
Terminal portions
UV circular dichroism
Amino acids
Chemical stability
Dichroism
Molecules
Nuclear magnetic resonance
Peptides
Resonance
Urea
Vaccines
Antigens
Amino acid
Epitope
HLA antigen class 2
HLA DR antigen
M protein
Peptide
Streptincor
Streptococcus vaccine
Unclassified drug
Alpha helix
Antigen binding
Antigen recognition
Article
Carboxy terminal sequence
Cellular immunity
Circular dichroism
Human tissue
Humoral immunity
Molecular interaction
Molecular stability
pH
Prediction
Priority journal
Protein domain
Protein folding
Protein structure
Antigen Presentation
Epitopes, B-Lymphocyte
Epitopes, T-Lymphocyte
Histocompatibility Antigens Class II
Nuclear Magnetic Resonance, Biomolecular
Protein Stability
Protein Structure, Secondary
Protein Structure, Tertiary
Streptococcal Infections
Streptococcal Vaccines
Acceso en línea:https://repository.urosario.edu.co/handle/10336/21890
https://doi.org/10.1074/jbc.M110.132118

Internet

https://repository.urosario.edu.co/handle/10336/21890
https://doi.org/10.1074/jbc.M110.132118

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