The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians
Objectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of...
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ir-10336-217322020-05-13T19:49:52Z The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians Franco, Juan-Sebastian Molano-González, Nicolas Rodríguez-Jímenez, Mónica Acosta-Ampudia, Yeny Mantilla, Rubén D. Amaya-Amaya, Jenny Rojas-Villarraga, Adriana Anaya, Juan-Manuel Anticuerpo fosfolípido Adulto Síndrome antifosfolípido Enfermedades Enfermedades del sistema inmunológico Síndrome antifosfolípido Lupus eritematoso sistémico Phospholipid antibody Factor reumatoide Rheumatoid factor Adult Antibody titer Antiphospholipid syndrome Objectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.Results: Although the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11-10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56- 16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63-14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjö gren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.Conclusions: APS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients. © 2014 Franco et al. 2014 2020-04-22T03:42:50Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1932-6203 https://repository.urosario.edu.co/handle/10336/21732 https://doi.org/10.1371/journal.pone.0110242 eng info:eu-repo/semantics/openAccess application/pdf |
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EdocUR - Universidad del Rosario |
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language |
Inglés (English) |
topic |
Anticuerpo fosfolípido Adulto Síndrome antifosfolípido Enfermedades Enfermedades del sistema inmunológico Síndrome antifosfolípido Lupus eritematoso sistémico Phospholipid antibody Factor reumatoide Rheumatoid factor Adult Antibody titer Antiphospholipid syndrome |
spellingShingle |
Anticuerpo fosfolípido Adulto Síndrome antifosfolípido Enfermedades Enfermedades del sistema inmunológico Síndrome antifosfolípido Lupus eritematoso sistémico Phospholipid antibody Factor reumatoide Rheumatoid factor Adult Antibody titer Antiphospholipid syndrome Franco, Juan-Sebastian Molano-González, Nicolas Rodríguez-Jímenez, Mónica Acosta-Ampudia, Yeny Mantilla, Rubén D. Amaya-Amaya, Jenny Rojas-Villarraga, Adriana Anaya, Juan-Manuel The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians |
description |
Objectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.Results: Although the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11-10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56- 16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63-14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjö gren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.Conclusions: APS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients. © 2014 Franco et al. |
format |
Artículo (Article) |
author |
Franco, Juan-Sebastian Molano-González, Nicolas Rodríguez-Jímenez, Mónica Acosta-Ampudia, Yeny Mantilla, Rubén D. Amaya-Amaya, Jenny Rojas-Villarraga, Adriana Anaya, Juan-Manuel |
author_facet |
Franco, Juan-Sebastian Molano-González, Nicolas Rodríguez-Jímenez, Mónica Acosta-Ampudia, Yeny Mantilla, Rubén D. Amaya-Amaya, Jenny Rojas-Villarraga, Adriana Anaya, Juan-Manuel |
author_sort |
Franco, Juan-Sebastian |
title |
The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians |
title_short |
The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians |
title_full |
The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians |
title_fullStr |
The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians |
title_full_unstemmed |
The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians |
title_sort |
coexistence of antiphospholipid syndrome and systemic lupus erythematosus in colombians |
publishDate |
2014 |
url |
https://repository.urosario.edu.co/handle/10336/21732 https://doi.org/10.1371/journal.pone.0110242 |
_version_ |
1667195762920914944 |
score |
12,131701 |