The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians

Objectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of...

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Autores Principales: Franco, Juan-Sebastian, Molano-González, Nicolas, Rodríguez-Jímenez, Mónica, Acosta-Ampudia, Yeny, Mantilla, Rubén D., Amaya-Amaya, Jenny, Rojas-Villarraga, Adriana, Anaya, Juan-Manuel
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2014
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Acceso en línea:https://repository.urosario.edu.co/handle/10336/21732
https://doi.org/10.1371/journal.pone.0110242
id ir-10336-21732
recordtype dspace
spelling ir-10336-217322020-05-13T19:49:52Z The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians Franco, Juan-Sebastian Molano-González, Nicolas Rodríguez-Jímenez, Mónica Acosta-Ampudia, Yeny Mantilla, Rubén D. Amaya-Amaya, Jenny Rojas-Villarraga, Adriana Anaya, Juan-Manuel Anticuerpo fosfolípido Adulto Síndrome antifosfolípido Enfermedades Enfermedades del sistema inmunológico Síndrome antifosfolípido Lupus eritematoso sistémico Phospholipid antibody Factor reumatoide Rheumatoid factor Adult Antibody titer Antiphospholipid syndrome Objectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.Results: Although the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11-10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56- 16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63-14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjö gren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.Conclusions: APS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients. © 2014 Franco et al. 2014 2020-04-22T03:42:50Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1932-6203 https://repository.urosario.edu.co/handle/10336/21732 https://doi.org/10.1371/journal.pone.0110242 eng info:eu-repo/semantics/openAccess application/pdf
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Anticuerpo fosfolípido
Adulto
Síndrome antifosfolípido
Enfermedades
Enfermedades del sistema inmunológico
Síndrome antifosfolípido
Lupus eritematoso sistémico
Phospholipid antibody
Factor reumatoide
Rheumatoid factor
Adult
Antibody titer
Antiphospholipid syndrome
spellingShingle Anticuerpo fosfolípido
Adulto
Síndrome antifosfolípido
Enfermedades
Enfermedades del sistema inmunológico
Síndrome antifosfolípido
Lupus eritematoso sistémico
Phospholipid antibody
Factor reumatoide
Rheumatoid factor
Adult
Antibody titer
Antiphospholipid syndrome
Franco, Juan-Sebastian
Molano-González, Nicolas
Rodríguez-Jímenez, Mónica
Acosta-Ampudia, Yeny
Mantilla, Rubén D.
Amaya-Amaya, Jenny
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians
description Objectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.Results: Although the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11-10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56- 16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63-14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjö gren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.Conclusions: APS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients. © 2014 Franco et al.
format Artículo (Article)
author Franco, Juan-Sebastian
Molano-González, Nicolas
Rodríguez-Jímenez, Mónica
Acosta-Ampudia, Yeny
Mantilla, Rubén D.
Amaya-Amaya, Jenny
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
author_facet Franco, Juan-Sebastian
Molano-González, Nicolas
Rodríguez-Jímenez, Mónica
Acosta-Ampudia, Yeny
Mantilla, Rubén D.
Amaya-Amaya, Jenny
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
author_sort Franco, Juan-Sebastian
title The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians
title_short The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians
title_full The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians
title_fullStr The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians
title_full_unstemmed The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians
title_sort coexistence of antiphospholipid syndrome and systemic lupus erythematosus in colombians
publishDate 2014
url https://repository.urosario.edu.co/handle/10336/21732
https://doi.org/10.1371/journal.pone.0110242
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score 12,131701