Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis

Objective: To estimate the efficacy of antibiotic prophylaxis to prevent urinary tract infection in patients (both gender) who undergo a cystoscopy with sterile urine. Materials and Methods: Search strategy (January 1980-December 2013) in Medline via PubMed, CENTRAL, and EMBASE. Additionally, we sea...

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Autores Principales: Garcia-Perdomo, Herney, Jiménez Mejías, Eladio, LOPEZ RAMOS, HUGO ENRIQUE
Formato: Revisión (Review)
Lenguaje:Inglés (English)
Publicado: 2015
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/21661
https://doi.org/10.1590/S1677-5538.IBJU.2014.0198
id ir-10336-21661
recordtype dspace
spelling ir-10336-216612020-05-13T19:48:07Z Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis Garcia-Perdomo, Herney Jiménez Mejías, Eladio LOPEZ RAMOS, HUGO ENRIQUE Randomized Controlled Trials as Topic Infección urinaria Meta análisis Antibióticos Enfermedades Enfermedades del aparato urinario Infecciones Urinary tract infections Cystoscopy Antibiotic prophylaxis Meta-Analysis Objective: To estimate the efficacy of antibiotic prophylaxis to prevent urinary tract infection in patients (both gender) who undergo a cystoscopy with sterile urine. Materials and Methods: Search strategy (January 1980-December 2013) in Medline via PubMed, CENTRAL, and EMBASE. Additionally, we searched databases for registered trials and conference abstracts, as well as reference lists of systematic reviews and included studies. Seven published randomized clinical trials (January 1, 1980 to December 31, 2013) were included in quantitative analyses with no language restrictions. Two independent reviewers collected data. Risk of bias was evaluated with the Cochrane Collaboration tool. We performed a fixed effect analyses due to statistical homogeneity. The primary outcome was urinary tract infection and the secondary was asymptomatic bacteriuria. The effect measure was the risk difference (RD) with 95% confidence interval. The planned interventions were: Antibiotic vs placebo; Antibiotic vs no intervention and Antibiotic vs any other intervention. Results: 3038 patients were found in seven studies. For the primary outcome, we included 5 studies and we found a RR 0.53 CI95% (0.31, 0.90) and a RD-0.012 CI95% (-0.023,-0.002), favoring antibiotic prophylaxis. For asymptomatic bacteriuria we included 6 studies and we found a RR 0.28 CI95% (0.20, 0.39) and a RD-0.055 CI95% (-0.07,-0.039), was found favoring prophylaxis. According to GRADE evaluation, we considered moderate quality of evidence for both outcomes. The subgroup analysis showed that only two studies were classified as having low risk of bias: Cam 2009 and García-Perdomo 2013. They showed no statistical differences (RD-0.009 CI95% -0.03, 0.011). Conclusions: Based on studies classified as low risk of bias, we found moderate evidence to not recommend the use of antibiotic prophylaxis to prevent urinary tract infection and asymptomatic bacteriuria in patients who undergo cystoscopy with sterile urine in an ambulatory setting. 2015-06 2020-04-17T16:00:22Z info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion 1677-5538 https://repository.urosario.edu.co/handle/10336/21661 https://doi.org/10.1590/S1677-5538.IBJU.2014.0198 eng info:eu-repo/semantics/openAccess application/pdf
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Randomized Controlled Trials as Topic
Infección urinaria
Meta análisis
Antibióticos
Enfermedades
Enfermedades del aparato urinario
Infecciones
Urinary tract infections
Cystoscopy
Antibiotic prophylaxis
Meta-Analysis
spellingShingle Randomized Controlled Trials as Topic
Infección urinaria
Meta análisis
Antibióticos
Enfermedades
Enfermedades del aparato urinario
Infecciones
Urinary tract infections
Cystoscopy
Antibiotic prophylaxis
Meta-Analysis
Garcia-Perdomo, Herney
Jiménez Mejías, Eladio
LOPEZ RAMOS, HUGO ENRIQUE
Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis
description Objective: To estimate the efficacy of antibiotic prophylaxis to prevent urinary tract infection in patients (both gender) who undergo a cystoscopy with sterile urine. Materials and Methods: Search strategy (January 1980-December 2013) in Medline via PubMed, CENTRAL, and EMBASE. Additionally, we searched databases for registered trials and conference abstracts, as well as reference lists of systematic reviews and included studies. Seven published randomized clinical trials (January 1, 1980 to December 31, 2013) were included in quantitative analyses with no language restrictions. Two independent reviewers collected data. Risk of bias was evaluated with the Cochrane Collaboration tool. We performed a fixed effect analyses due to statistical homogeneity. The primary outcome was urinary tract infection and the secondary was asymptomatic bacteriuria. The effect measure was the risk difference (RD) with 95% confidence interval. The planned interventions were: Antibiotic vs placebo; Antibiotic vs no intervention and Antibiotic vs any other intervention. Results: 3038 patients were found in seven studies. For the primary outcome, we included 5 studies and we found a RR 0.53 CI95% (0.31, 0.90) and a RD-0.012 CI95% (-0.023,-0.002), favoring antibiotic prophylaxis. For asymptomatic bacteriuria we included 6 studies and we found a RR 0.28 CI95% (0.20, 0.39) and a RD-0.055 CI95% (-0.07,-0.039), was found favoring prophylaxis. According to GRADE evaluation, we considered moderate quality of evidence for both outcomes. The subgroup analysis showed that only two studies were classified as having low risk of bias: Cam 2009 and García-Perdomo 2013. They showed no statistical differences (RD-0.009 CI95% -0.03, 0.011). Conclusions: Based on studies classified as low risk of bias, we found moderate evidence to not recommend the use of antibiotic prophylaxis to prevent urinary tract infection and asymptomatic bacteriuria in patients who undergo cystoscopy with sterile urine in an ambulatory setting.
format Revisión (Review)
author Garcia-Perdomo, Herney
Jiménez Mejías, Eladio
LOPEZ RAMOS, HUGO ENRIQUE
author_facet Garcia-Perdomo, Herney
Jiménez Mejías, Eladio
LOPEZ RAMOS, HUGO ENRIQUE
author_sort Garcia-Perdomo, Herney
title Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis
title_short Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis
title_full Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis
title_fullStr Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis
title_full_unstemmed Efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : A systematic review and meta-analysis
title_sort efficacy of antibiotic prophylaxis in cystoscopy to prevent urinary tract infection : a systematic review and meta-analysis
publishDate 2015
url https://repository.urosario.edu.co/handle/10336/21661
https://doi.org/10.1590/S1677-5538.IBJU.2014.0198
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