Failure of antiepileptic drugs in controlling seizures in epilepsy: What do we do next?

Medically intractable epilepsy is a clinical condition of concern that arises when a patient with epilepsy suffers seizures, despite a trial of two or more antiepileptic drugs (AEDs) suitable for the type of epilepsy that are prescribed at maximum tolerated doses, does not achieve control of seizure...

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Autores Principales: Galindo-Mendez, B., Mayor, L.C., Velandia-Hurtado, Fernando, Calderon-Ospina, C.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2015
Materias:
Acceso en línea:https://repository.urosario.edu.co/handle/10336/21507
id ir-10336-21507
recordtype dspace
spelling ir-10336-215072020-04-04T01:04:17Z Failure of antiepileptic drugs in controlling seizures in epilepsy: What do we do next? Galindo-Mendez, B. Mayor, L.C. Velandia-Hurtado, Fernando Calderon-Ospina, C. Epilepsy Malformations of cortical development Cortical dysplasia–focal epilepsy syndrome Anticonvulsants Drug resistance Medically intractable epilepsy is a clinical condition of concern that arises when a patient with epilepsy suffers seizures, despite a trial of two or more antiepileptic drugs (AEDs) suitable for the type of epilepsy that are prescribed at maximum tolerated doses, does not achieve control of seizures. This diagnosis could be related to cortical dysplasias. We report the case of a 5-year-old girl with a previous normal neurological development and no family history of epilepsy who presented with focal-type seizures at age 4. She started treatment by taking different AEDs for seizure control. She continued having frequent seizures that sometimes progressed to generalized seizures and status epilepticus. After a focal cortical resection performed in the area where interictal spikes were detected, the pathology confirmed a type IIb cortical dysplasia as the cause of the epilepsy. This article discusses cortical dysplasias as a cause of pharmacoresistant epilepsy and its treatment. © 2015 The Authors. 2015 2020-04-04T01:04:16Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2213-3232 https://repository.urosario.edu.co/handle/10336/21507 10.1016/j.ebcr.2015.03.004 eng info:eu-repo/semantics/openAccess application/pdf
institution EdocUR - Universidad del Rosario
collection DSpace
language Inglés (English)
topic Epilepsy
Malformations of cortical development
Cortical dysplasia–focal epilepsy syndrome
Anticonvulsants
Drug resistance
spellingShingle Epilepsy
Malformations of cortical development
Cortical dysplasia–focal epilepsy syndrome
Anticonvulsants
Drug resistance
Galindo-Mendez, B.
Mayor, L.C.
Velandia-Hurtado, Fernando
Calderon-Ospina, C.
Failure of antiepileptic drugs in controlling seizures in epilepsy: What do we do next?
description Medically intractable epilepsy is a clinical condition of concern that arises when a patient with epilepsy suffers seizures, despite a trial of two or more antiepileptic drugs (AEDs) suitable for the type of epilepsy that are prescribed at maximum tolerated doses, does not achieve control of seizures. This diagnosis could be related to cortical dysplasias. We report the case of a 5-year-old girl with a previous normal neurological development and no family history of epilepsy who presented with focal-type seizures at age 4. She started treatment by taking different AEDs for seizure control. She continued having frequent seizures that sometimes progressed to generalized seizures and status epilepticus. After a focal cortical resection performed in the area where interictal spikes were detected, the pathology confirmed a type IIb cortical dysplasia as the cause of the epilepsy. This article discusses cortical dysplasias as a cause of pharmacoresistant epilepsy and its treatment. © 2015 The Authors.
format Artículo (Article)
author Galindo-Mendez, B.
Mayor, L.C.
Velandia-Hurtado, Fernando
Calderon-Ospina, C.
author_facet Galindo-Mendez, B.
Mayor, L.C.
Velandia-Hurtado, Fernando
Calderon-Ospina, C.
author_sort Galindo-Mendez, B.
title Failure of antiepileptic drugs in controlling seizures in epilepsy: What do we do next?
title_short Failure of antiepileptic drugs in controlling seizures in epilepsy: What do we do next?
title_full Failure of antiepileptic drugs in controlling seizures in epilepsy: What do we do next?
title_fullStr Failure of antiepileptic drugs in controlling seizures in epilepsy: What do we do next?
title_full_unstemmed Failure of antiepileptic drugs in controlling seizures in epilepsy: What do we do next?
title_sort failure of antiepileptic drugs in controlling seizures in epilepsy: what do we do next?
publishDate 2015
url https://repository.urosario.edu.co/handle/10336/21507
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score 11,828437