Vista Equipo: Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression

Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression

Background Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD betw...

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Autores Principales:	Mendoza-Pinto, C., Rojas-Villarraga, A., Molano-González, Nicolas, Jimenez-Herrera, E.A., De La Luz Leon-Vazquez, M., Montiel-Jarquõn, A., Garcõa-Carrasco, M., Cervera, R., Mendoza-Pinto, Claudia, Rojas-Villarraga, Adriana, Jiménez-Herrera, Erick A., León-Vázquez, María de la Luz, Montiel-Jarquín, Alvaro, García-Carrasco, Mario, Cervera, Ricard
Formato:	Revisión (Review)
Lenguaje:	Inglés (English)
Publicado:	2018
Materias:	Glucocorticoides Densidad osea Terapia con corticosteroides Asociación de la enfermedad Fisiología humana Lupus eritematoso Fracturas Glucocorticoid Bone density Corticosteroid therapy Disease association Evidence based medicine Gender Human Medication therapy management Review Spine fracture Systematic review Systemic lupus erythematosus
Acceso en línea:	https://repository.urosario.edu.co/handle/10336/20324 https://doi.org/10.1371/journal.pone.0196113

id	ir-10336-20324
recordtype	dspace
spelling	ir-10336-203242022-08-29T20:21:38Z Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression Mendoza-Pinto, C. Rojas-Villarraga, A. Molano-González, Nicolas Jimenez-Herrera, E.A. De La Luz Leon-Vazquez, M. Montiel-Jarquõn, A. Garcõa-Carrasco, M. Cervera, R. Mendoza-Pinto, Claudia Rojas-Villarraga, Adriana Molano-González, Nicolas Jiménez-Herrera, Erick A. León-Vázquez, María de la Luz Montiel-Jarquín, Alvaro García-Carrasco, Mario Cervera, Ricard Glucocorticoides Densidad osea Terapia con corticosteroides Asociación de la enfermedad Fisiología humana Glucocorticoides Lupus eritematoso Fracturas Glucocorticoid Bone density Corticosteroid therapy Disease association Evidence based medicine Gender Human Medication therapy management Review Spine fracture Systematic review Systemic lupus erythematosus Background Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD between SLE patients and healthy controls and 2) to evaluate the relationship between BMD and glucocorticoid therapy and VF in SLE patients. Methods and findings Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). Prospective longitudinal and cross-sectional studies were considered for review. We evaluated the quality of the evidence included using the Oxford Centre for evidence- based medicine (EBM) Levels of Evidence. In total, 38 articles were identified and analyzed (3442 SLE cases and 6198 controls) in the analysis of BMD (9232 women and 408 men). There were significant differences in mean BMD between SLE patients and controls. BMD mean difference in cases/controls: -0.0566 95% CI (-0.071, -0.0439; p = > 0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received glucocorticoid (GCT) therapy. 694 SLE patients were included in the analysis of VF (189 with VF vs. 505 without VF). Patients with VF had lower BMD than patients without VF (BMD mean difference without VF/with VF: 0.033 (95%CI: 0.006±0.060); p-value: 0.0156). Conclusions Patients with SLE had lower BMD than healthy controls. Moreover, SLE patients with VF had lower BMD than patients without VF. However, our data did not show that GCT therapy had an impact on BMD. © 2018 van den Berg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2018 2019-09-24T15:03:47Z info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion 1932-6203 https://repository.urosario.edu.co/handle/10336/20324 https://doi.org/10.1371/journal.pone.0196113 eng info:eu-repo/semantics/openAccess application/pdf instname:Universidad del Rosario
institution	EdocUR - Universidad del Rosario
collection	DSpace
language	Inglés (English)
topic	Glucocorticoides Densidad osea Terapia con corticosteroides Asociación de la enfermedad Fisiología humana Glucocorticoides Lupus eritematoso Fracturas Glucocorticoid Bone density Corticosteroid therapy Disease association Evidence based medicine Gender Human Medication therapy management Review Spine fracture Systematic review Systemic lupus erythematosus
spellingShingle	Glucocorticoides Densidad osea Terapia con corticosteroides Asociación de la enfermedad Fisiología humana Glucocorticoides Lupus eritematoso Fracturas Glucocorticoid Bone density Corticosteroid therapy Disease association Evidence based medicine Gender Human Medication therapy management Review Spine fracture Systematic review Systemic lupus erythematosus Mendoza-Pinto, C. Rojas-Villarraga, A. Molano-González, Nicolas Jimenez-Herrera, E.A. De La Luz Leon-Vazquez, M. Montiel-Jarquõn, A. Garcõa-Carrasco, M. Cervera, R. Mendoza-Pinto, Claudia Rojas-Villarraga, Adriana Molano-González, Nicolas Jiménez-Herrera, Erick A. León-Vázquez, María de la Luz Montiel-Jarquín, Alvaro García-Carrasco, Mario Cervera, Ricard Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression
description	Background Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD between SLE patients and healthy controls and 2) to evaluate the relationship between BMD and glucocorticoid therapy and VF in SLE patients. Methods and findings Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). Prospective longitudinal and cross-sectional studies were considered for review. We evaluated the quality of the evidence included using the Oxford Centre for evidence- based medicine (EBM) Levels of Evidence. In total, 38 articles were identified and analyzed (3442 SLE cases and 6198 controls) in the analysis of BMD (9232 women and 408 men). There were significant differences in mean BMD between SLE patients and controls. BMD mean difference in cases/controls: -0.0566 95% CI (-0.071, -0.0439; p = > 0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received glucocorticoid (GCT) therapy. 694 SLE patients were included in the analysis of VF (189 with VF vs. 505 without VF). Patients with VF had lower BMD than patients without VF (BMD mean difference without VF/with VF: 0.033 (95%CI: 0.006±0.060); p-value: 0.0156). Conclusions Patients with SLE had lower BMD than healthy controls. Moreover, SLE patients with VF had lower BMD than patients without VF. However, our data did not show that GCT therapy had an impact on BMD. © 2018 van den Berg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
format	Revisión (Review)
author	Mendoza-Pinto, C. Rojas-Villarraga, A. Molano-González, Nicolas Jimenez-Herrera, E.A. De La Luz Leon-Vazquez, M. Montiel-Jarquõn, A. Garcõa-Carrasco, M. Cervera, R. Mendoza-Pinto, Claudia Rojas-Villarraga, Adriana Molano-González, Nicolas Jiménez-Herrera, Erick A. León-Vázquez, María de la Luz Montiel-Jarquín, Alvaro García-Carrasco, Mario Cervera, Ricard
author_facet	Mendoza-Pinto, C. Rojas-Villarraga, A. Molano-González, Nicolas Jimenez-Herrera, E.A. De La Luz Leon-Vazquez, M. Montiel-Jarquõn, A. Garcõa-Carrasco, M. Cervera, R. Mendoza-Pinto, Claudia Rojas-Villarraga, Adriana Molano-González, Nicolas Jiménez-Herrera, Erick A. León-Vázquez, María de la Luz Montiel-Jarquín, Alvaro García-Carrasco, Mario Cervera, Ricard
author_sort	Mendoza-Pinto, C.
title	Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression
title_short	Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression
title_full	Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression
title_fullStr	Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression
title_full_unstemmed	Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression
title_sort	bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : a systematic review and meta-regression
publishDate	2018
url	https://repository.urosario.edu.co/handle/10336/20324 https://doi.org/10.1371/journal.pone.0196113
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score	12,131701

Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression

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