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Inefficient DNA repair is an aging-related modifier of parkinson's disease

The underlying relation between Parkinson's disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus between DNA damage accumulation, aging, and PD by assessing aging-relat...

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Detalles Bibliográficos
Autores Principales: Sepe, Sara, Milanese, Chiara, Gabriels, Sylvia, Derks, Kasper W.J., Payan-Gomez, Cesar, van IJcken, Wilfred F.J., Rijksen, Yvonne M.A., Nigg, Alex L., Moreno, Sandra, Cerri, Silvia, Blandini, Fabio, Hoeijmakers, Jan H.J., Mastroberardino, Pier G.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2016
Materias:
Alpha Synuclein
Cre Recombinase
Excision Repair Cross Complementing Protein 1
Histone H2Ax
Histone H2Ax Gamma
Unclassified Drug
Dna Binding Protein
Endonuclease
Ercc1 Protein, Mouse
Aging
Animal Experiment
Animal Model
Article
Autonomic Innervation
Controlled Study
Disease Association
Dna Damage
Dna Repair
Dopaminergic System
Double Stranded Dna Break
Down Regulation
Enzyme Activity
Ercc1 Gene
Excision Repair
Gene Expression
Gene Mutation
Human
Human Cell
Mitochondrial Respiration
Mouse
Neuropathology
Nonhuman
Oxidation Reduction State
Parkinson Disease
Priority Journal
Protein Expression
Protein Homeostasis
Protein Phosphorylation
Rna Sequence
Skin Fibroblast
Upregulation
Animal
Corpus Striatum
Dopaminergic Nerve Cell
Fibroblast
Metabolism
Pathology
Ultrastructure
Animals
Dna-Binding Proteins
Dopaminergic Neurons
Endonucleases
Fibroblasts
Humans
Mice
Enfermedades
Enfermedad de parkinson
Edad adulta
Vejez
Acceso en línea:http://repository.urosario.edu.co/handle/10336/18940

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