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Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

Sjögren’s syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debilitating fatigue. Dysregulation of type I interferon...

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Detalles Bibliográficos
Autores Principales: Li, He, Reksten, Tove Ragna, Ice, John A., Kelly, Jennifer A., Adrianto, Indra, Rasmussen, Astrid, Wang, Shaofeng, He, Bo, Grundahl, Kiely M., Glenn, Stuart B., Miceli-Richard, Corinne, Bowman, Simon, Lester, Sue, Eriksson, Per, Eloranta, Maija-Leena, Brun, Johan G., Gøransson, Lasse G., Harboe, Erna, Guthridge, Joel M., Kaufman, Kenneth M., Kvarnström, Marika, Cunninghame Graham, Deborah S., Patel, Ketan, Adler, Adam J., Farris, A. Darise, Brennan, Michael T., Chodosh, James, Gopalakrishnan, Rajaram, Weisman, Michael H., Venuturupalli, Swamy, Wallace, Daniel J., Hefner, Kimberly S., Houston, Glen D., Huang, Andrew J. W., Hughes, Pamela J., Lewis, David M., Radfar, Lida, Vista, Evan S., Contessa E., Edgar, Rohrer, Michael D., Stone, Donald U., Vyse, Timothy J., Harley, John B., Gaffney, Patrick M., James, Judith A., Turner, Sean, Alevizos, Ilias, Anaya, Juan-Manuel, Rhodus, Nelson L., Segal, Barbara M., Montgomery, Courtney G., Scofield, R. Hal, Kovats, Susan, Mariette, Xavier, Rönnblom, Lars, Witte, Torsten, Rischmueller, Maureen, Wahren-Herlenius, Marie, Omdal, Roald, Jonsson, Roland, Ng, Wan-Fai, Nordmark, Gunnel, Lessard, Christopher J., Sivils, Kathy L.
Formato: Artículo (Article)
Lenguaje:Inglés (English)
Publicado: 2017
Materias:
Article
Female
Humans
Un-explained visual loss
Silicone oil
Vitrectomy
Retinal detachment
Müller cells
Neuronal apoptosis
Potassium
Acceso en línea:http://repository.urosario.edu.co/handle/10336/18812
https://doi.org/10.1371/journal.pgen.1006820

Internet

http://repository.urosario.edu.co/handle/10336/18812
https://doi.org/10.1371/journal.pgen.1006820

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