Clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy

Objective: Epilepsy is a common neurologic disorder affecting 1% of the world population with one-third of these patients failing to have seizure control for more than one year. Clobazam is a long-acting benzodiazepine used worldwide for the treatment of epilepsy. This antiepileptic drug has demon...

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Autores Principales: Martínez-Micolta, Paula, Lemus, Hernan Nicolás
Otros Autores: Mayor, Luis Carlos
Formato: Tesis de maestría (Master Thesis)
Lenguaje:Español (Spanish)
Publicado: Universidad del Rosario 2016
Materias:
Acceso en línea:http://repository.urosario.edu.co/handle/10336/11819
id ir-10336-11819
recordtype dspace
spelling ir-10336-118192021-03-01T19:22:52Z Clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy Case-series Martínez-Micolta, Paula Lemus, Hernan Nicolás Mayor, Luis Carlos add-on treatment epilepsy antiepileptic drugs Clobazam Enfermedades Neurofisiología Epilepsia Enfermedades del sistema nervioso Neurología Objective: Epilepsy is a common neurologic disorder affecting 1% of the world population with one-third of these patients failing to have seizure control for more than one year. Clobazam is a long-acting benzodiazepine used worldwide for the treatment of epilepsy. This antiepileptic drug has demonstrated great clinical benefits with mild side effects. The objective of this study was to better understand the efficacy of clobazam treatment on adult patients with refractory epilepsy. Design: A retrospective review of 44 adult patients with diagnosis of epilepsy that were seen at our Epilepsy Clinic between January 2014 and May 2015. Setting: An outpatient epilepsy clinic at the Hospital Universitario Fundación Santa Fe de Bogota, Colombia. Participants: 44 adult patients with diagnosis of epilepsy. Measurements: Seizure frequency, adverse effects and the use of concomitant AEDs were reviewed in each of the patient´s clinical charts. Results: The responder rate of patients with clobazam was 52% at 3 months, 50% at 6 months and 55% at 12 month. Seizure freedom rates at 3, 6 and 12 months were 18%, 25% and 25% respectively. Clobazam related adverse events occurred only in four patients (9%) at the end of the twelve months with somnolence being the most common. Conclusion: These findings suggest that clobazam treatment in adult patients with focal or generalized epilepsy is effective and safe. Its use should be considered early when first-line agents fail to provide seizure control. Ninguno 2016-01-19 2016-03-07T21:44:23Z info:eu-repo/semantics/masterThesis info:eu-repo/semantics/acceptedVersion http://repository.urosario.edu.co/handle/10336/11819 spa info:eu-repo/semantics/openAccess application/pdf Universidad del Rosario Especialización en Neurofisiología Clínica Facultad de Medicina reponame:Repositorio Institucional EdocUR instname:Universidad del Rosario Gauthier AC, Mattson RH. Clobazam: A Safe, Efficacious, and Newly Rediscovered Therapeutic for Epilepsy. CNS Neurosci Ther. 2015;21:543-8. Glauser T, Ben-Menachem E, Bourgeois B, et al. ILAE treatment guidelines: Evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2006;47:1094-1120.
institution EdocUR - Universidad del Rosario
collection DSpace
language Español (Spanish)
topic add-on treatment
epilepsy
antiepileptic drugs
Clobazam
Enfermedades
Neurofisiología
Epilepsia
Enfermedades del sistema nervioso
Neurología
spellingShingle add-on treatment
epilepsy
antiepileptic drugs
Clobazam
Enfermedades
Neurofisiología
Epilepsia
Enfermedades del sistema nervioso
Neurología
Martínez-Micolta, Paula
Lemus, Hernan Nicolás
Clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy
description Objective: Epilepsy is a common neurologic disorder affecting 1% of the world population with one-third of these patients failing to have seizure control for more than one year. Clobazam is a long-acting benzodiazepine used worldwide for the treatment of epilepsy. This antiepileptic drug has demonstrated great clinical benefits with mild side effects. The objective of this study was to better understand the efficacy of clobazam treatment on adult patients with refractory epilepsy. Design: A retrospective review of 44 adult patients with diagnosis of epilepsy that were seen at our Epilepsy Clinic between January 2014 and May 2015. Setting: An outpatient epilepsy clinic at the Hospital Universitario Fundación Santa Fe de Bogota, Colombia. Participants: 44 adult patients with diagnosis of epilepsy. Measurements: Seizure frequency, adverse effects and the use of concomitant AEDs were reviewed in each of the patient´s clinical charts. Results: The responder rate of patients with clobazam was 52% at 3 months, 50% at 6 months and 55% at 12 month. Seizure freedom rates at 3, 6 and 12 months were 18%, 25% and 25% respectively. Clobazam related adverse events occurred only in four patients (9%) at the end of the twelve months with somnolence being the most common. Conclusion: These findings suggest that clobazam treatment in adult patients with focal or generalized epilepsy is effective and safe. Its use should be considered early when first-line agents fail to provide seizure control.
author2 Mayor, Luis Carlos
author_facet Mayor, Luis Carlos
Martínez-Micolta, Paula
Lemus, Hernan Nicolás
format Tesis de maestría (Master Thesis)
author Martínez-Micolta, Paula
Lemus, Hernan Nicolás
author_sort Martínez-Micolta, Paula
title Clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy
title_short Clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy
title_full Clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy
title_fullStr Clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy
title_full_unstemmed Clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy
title_sort clinical experience of clobazam as add-on treatment in a cohort of adults with epilepsy
publisher Universidad del Rosario
publishDate 2016
url http://repository.urosario.edu.co/handle/10336/11819
_version_ 1694382472855289856
score 12,131701