Vista Equipo: Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines

Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines

This study covers an area of great importance in the research of breast cancer, related to the study of the effects of both estrogens (E2) and anti-estrogens (Tamoxifen) on chromosomes and of modulation of gene expression. Considering that breast cancer is a very heterogeneous disease and that patie...

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Detalles Bibliográficos
Autor Principal:	Rondón Lagos, Sandra Milena
Otros Autores:	Sapino, Anna
Formato:	Tesis de doctorado (Doctoral Thesis)
Lenguaje:	Español (Spanish)
Publicado:	Universidad del Rosario 2014
Materias:	Breast Cancer, Chromosomal abnormalities, M-FISH, Tamoxifen, 17B-Estradiol Enfermedades Breast Cancer, Chromosomal abnormalities, M-FISH, Tamoxifen, 17B-estradiol 17β-estradiol Ingeniería biomédica Genética Cromosomas
Acceso en línea:	http://repository.urosario.edu.co/handle/10336/10215

id	ir-10336-10215
recordtype	dspace
spelling	ir-10336-102152019-09-19T12:37:54Z Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines Rondón Lagos, Sandra Milena Sapino, Anna Breast Cancer, Chromosomal abnormalities, M-FISH, Tamoxifen, 17B-Estradiol Enfermedades Breast Cancer, Chromosomal abnormalities, M-FISH, Tamoxifen, 17B-estradiol 17β-estradiol Ingeniería biomédica Genética Cromosomas This study covers an area of great importance in the research of breast cancer, related to the study of the effects of both estrogens (E2) and anti-estrogens (Tamoxifen) on chromosomes and of modulation of gene expression. Considering that breast cancer is a very heterogeneous disease and that patients respond differently to treatment, the identification of chromosomal abnormalities as well as genes responsive to 17β-estradiol (E2) and Tamoxifen (TAM) could provide the necessary framework to understand the complex effects of this hormone in target cells and could explain, at least in part, the development of cellular resistance to TAM treatment and the subsequent best therapeutic option. In this order of ideas, we determined the effects of E2 and TAM on the chromosomes and on the modulation of gene expression in four breast cancer cell lines, which represent three of the five subtypes of breast cancer known at present. The results are presented in six chapters - each one has a group of the results achieved around the cytogenetic characteristics and gene expression profiles of four cell lines and the effects of E2 and TAM incubation on those. The first chapter describes the main features of breast cancer, furthering the use and effects of E2 and TAM treatment. This study covers an area of great importance in the research of breast cancer, related to the study of the effects of both estrogens (E2) and anti-estrogens (Tamoxifen) on chromosomes and of modulation of gene expression. Considering that breast cancer is a very heterogeneous disease and that patients respond differently to treatment, the identification of chromosomal abnormalities as well as genes responsive to 17β-estradiol (E2) and Tamoxifen (TAM) could provide the necessary framework to understand the complex effects of this hormone in target cells and could explain, at least in part, the development of cellular resistance to TAM treatment and the subsequent best therapeutic option. In this order of ideas, we determined the effects of E2 and TAM on the chromosomes and on the modulation of gene expression in four breast cancer cell lines, which represent three of the five subtypes of breast cancer known at present. The results are presented in six chapters - each one has a group of the results achieved around the cytogenetic characteristics and gene expression profiles of four cell lines and the effects of E2 and TAM incubation on those. The first chapter describes the main features of breast cancer, furthering the use and effects of E2 and TAM treatment. Eracol y Colciencias 2014-07-29 2015-02-23T12:43:20Z info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/acceptedVersion http://repository.urosario.edu.co/handle/10336/10215 spa info:eu-repo/semantics/openAccess application/pdf Universidad del Rosario Doctorado en Ciencias Biomédicas Facultad de Ciencias Naturales y Matemáticas instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR
institution	EdocUR - Universidad del Rosario
collection	DSpace
language	Español (Spanish)
topic	Breast Cancer, Chromosomal abnormalities, M-FISH, Tamoxifen, 17B-Estradiol Enfermedades Breast Cancer, Chromosomal abnormalities, M-FISH, Tamoxifen, 17B-estradiol 17β-estradiol Ingeniería biomédica Genética Cromosomas
spellingShingle	Breast Cancer, Chromosomal abnormalities, M-FISH, Tamoxifen, 17B-Estradiol Enfermedades Breast Cancer, Chromosomal abnormalities, M-FISH, Tamoxifen, 17B-estradiol 17β-estradiol Ingeniería biomédica Genética Cromosomas Rondón Lagos, Sandra Milena Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines
description	This study covers an area of great importance in the research of breast cancer, related to the study of the effects of both estrogens (E2) and anti-estrogens (Tamoxifen) on chromosomes and of modulation of gene expression. Considering that breast cancer is a very heterogeneous disease and that patients respond differently to treatment, the identification of chromosomal abnormalities as well as genes responsive to 17β-estradiol (E2) and Tamoxifen (TAM) could provide the necessary framework to understand the complex effects of this hormone in target cells and could explain, at least in part, the development of cellular resistance to TAM treatment and the subsequent best therapeutic option. In this order of ideas, we determined the effects of E2 and TAM on the chromosomes and on the modulation of gene expression in four breast cancer cell lines, which represent three of the five subtypes of breast cancer known at present. The results are presented in six chapters - each one has a group of the results achieved around the cytogenetic characteristics and gene expression profiles of four cell lines and the effects of E2 and TAM incubation on those. The first chapter describes the main features of breast cancer, furthering the use and effects of E2 and TAM treatment.
author2	Sapino, Anna
author_facet	Sapino, Anna Rondón Lagos, Sandra Milena
format	Tesis de doctorado (Doctoral Thesis)
author	Rondón Lagos, Sandra Milena
author_sort	Rondón Lagos, Sandra Milena
title	Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines
title_short	Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines
title_full	Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines
title_fullStr	Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines
title_full_unstemmed	Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines
title_sort	effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines
publisher	Universidad del Rosario
publishDate	2014
url	http://repository.urosario.edu.co/handle/10336/10215
_version_	1645141835965792256
score	12,111491

Effects of 17β-estradiol and tamoxifen on the induction of chromosomal abnormalities and on the expression of her2 gene in breast cancer cell lines

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